caa a22 4500 469120215 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244968 doi (NATIONALLICENCE)springer-10.1007/BF02244968 Effects of the putative dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 on the discriminative stimulus properties of cocaine [Elektronische Daten] [Patrick Callahan, Montford Piercey, Kathryn Cunningham] Recent evidence suggests that the putative dopamine (DA) autoreceptor antagonists, (+)-AJ 76 and (+)-UH 232, share some neurochemical and behavioral effects with both psychostimulants and neuroleptics. The ability of (+)-AJ 76 and (+)-UH 232 to mimic or antagonize the stimulus effects of cocaine was investigated in rats trained to discriminate 5 mg/kg (N=8) or 10 mg/kg (N=8) of cocaine from saline in a two-lever, water-reinforced, drug discrimination task. In the cocaine (10 mg/kg) group, administration of (+)-AJ 76 (2.5-20 mg/kg) engendered only a partial substitution for cocaine (maximum 60% cocaine-lever responses). Given in combination with cocaine (10 mg/kg), (+)-AJ 76 (2.5-40 mg/kg) did not significantly attenuate the cocaine cue. A fixed dose of (+)-AJ 76 (2.5 or 10 mg/kg) plus various doses of cocaine (1.25-5 mg/kg) did not alter the cocaine dose-response curve. (+)-UH 232 (2-16 mg/kg) produced primarily saline-appropriate responding in rats trained to discriminate 5 mg/kg of cocaine and was unable to block the interoceptive cocaine state when given in combination with cocaine (5 mg/kg). (+)-UH 232 (2 or 8 mg/kg) also did not alter the cocaine dose-response curve. These results suggest that (+)-AJ 76 and (+)-UH 232 elicit only weak or no cocaine-like stimulus effects and, unlike neuroleptics, do not attenuate the cocaine cue. Springer-Verlag, 1992 Cocaine nationallicence Dopamine autoreceptor nationallicence (+)-AJ 76 nationallicence (+)-UH 232 nationallicence Drug discrimination nationallicence Callahan Patrick Department of Pharmacology and Toxicology, University of Texas Medical Branch, 77550, Galveston, TX, USA aut Piercey Montford CNS Research 7251-209-4, The Upjohn Company, 49001, Kalamazoo, MI, USA aut Cunningham Kathryn Department of Pharmacology and Toxicology, University of Texas Medical Branch, 77550, Galveston, TX, USA aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 73-77 0033-3158 107:1<73 1992 107 213 https://doi.org/10.1007/BF02244968 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244968 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Callahan Patrick Department of Pharmacology and Toxicology, University of Texas Medical Branch, 77550, Galveston, TX, USA aut NATIONALLICENCE 700 1- Piercey Montford CNS Research 7251-209-4, The Upjohn Company, 49001, Kalamazoo, MI, USA aut NATIONALLICENCE 700 1- Cunningham Kathryn Department of Pharmacology and Toxicology, University of Texas Medical Branch, 77550, Galveston, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 73-77 0033-3158 107:1<73 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer