caa a22 4500 469120223 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244960 doi (NATIONALLICENCE)springer-10.1007/BF02244960 Casey Daniel Psychiatry Research and Psychopharmacology, VA Medical Center, 3710 S.W. US Veterans Hospital Road, 97207, Portland, OR, USA aut Dopamine D1 (SCH 23390) and D2 (haloperidol) antagonists in drug-naive monkeys [Elektronische Daten] [Daniel Casey] The ability of dopamine D1 antagonists to produce acute extrapyramidal syndromes (EPS) in nonhuman primates is unclear. Some studies in monkeys show that D1 antagonists produce acute dystonia, whereas other studies do not report these effects. The central issues that have yielded conflicting results revolve around prior treatment status (neuroleptic-naive versus neuroleptic sensitized) and route of administration (oral versus parenteral). In this study, separate groups of neuroleptic drug-naive cebus monkeys were tested once weekly with intramuscularly administered SCH 23390, a D1 antagonist, or haloperidol, a D2 antagonist, across a dose range of 0.01-0.25 mg/kg, and a saline control. Both active drugs, but not saline, produced clinically identical syndromes of acute dystonia and bradykinesia, though haloperidol induced higher symptom scores over a longer duration. Sedation and locomotor activity were unchanged by SCH 23390, but decreased with haloperidol. Factors regarding acute EPS liability in nonhuman primate models and clinical implications in man are discussed. Springer-Verlag, 1992 Neuroleptics nationallicence Dopamine receptor subtypes nationallicence SCH 23390 nationallicence Haloperidol nationallicence Extrapyramidal syndromes nationallicence Nonhuman primates nationallicence Psychopharmacology Springer-Verlag 107/1(1992-05-01), 18-22 0033-3158 107:1<18 1992 107 213 https://doi.org/10.1007/BF02244960 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244960 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Casey Daniel Psychiatry Research and Psychopharmacology, VA Medical Center, 3710 S.W. US Veterans Hospital Road, 97207, Portland, OR, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 18-22 0033-3158 107:1<18 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer