caa a22 4500 469120258 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244975 doi (NATIONALLICENCE)springer-10.1007/BF02244975 Evidence for separate neuronal mechanisms for the discriminative stimulus and catalepsy induced by Δ9-THC in the rat [Elektronische Daten] [W. Prescott, L. Gold, B. Martin] The cataleptogenic effect of Δ9-THC was compared to its discriminative stimulus effects in rats. The ED50s for the discriminative stimulus and catalepsy were 0.8 and 4.0 mg/kg, respectively, while their time courses were very similar. The ED50 of Δ9-THC for catalepsy in experimentally naive rats was not different from that in rats trained with the drug discrimination procedure, indicating that the cataleptogenic effect was not appreciably attenuated by long-term exposure to low doses of Δ9-THC. Pharmacologically, the catalepsy produced by Δ9-THC more closely resembled that of haloperidol than of morphine, since anticholinergic pretreatment eliminated the Δ9-THC-induced catalepsy while pre-treatment with naloxone had no effect. Although the cataleptogenic effect of Δ9-THC could be pharmacologically manipulated by anticholinergic pre-treatment, its discriminative stimulus effects were not changed in the same animals. These results demonstrate that distinctive mechanisms of action exist for these cannabinoid-induced behaviors. Springer-Verlag, 1992 Discriminative stimulus nationallicence Catalepsy nationallicence Marijuana nationallicence Δ9-Tetrahydrocannabinol nationallicence Opiate nationallicence Neuroleptic nationallicence Rats nationallicence Prescott W. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut Gold L. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut Martin B. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 117-124 0033-3158 107:1<117 1992 107 213 https://doi.org/10.1007/BF02244975 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244975 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Prescott W. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Gold L. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut NATIONALLICENCE 700 1- Martin B. Department of Pharmacology and Toxicology, Commonwealth of Virginia Drug Abuse Research Center, Medical College of Virginia, Virginia Commonwealth University, P.O. Box 613-MCV Station, 23298, Richmond, VA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 117-124 0033-3158 107:1<117 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer