caa a22 4500 469120290 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920501xx s 000 0 eng 10.1007/BF02244959 doi (NATIONALLICENCE)springer-10.1007/BF02244959 Relationship between drug plasma concentrations and psychomotor performance after single doses of ethanol and benzodiazepines [Elektronische Daten] [John Ingum, Roald Bjørklund, Anders Bjørneboe, Asbjørg Christophersen, Ellen Dahlin, Jørg Mørland] In a placebo controlled, crossover study psychomotor effects of single doses of diazepam, 10 and 20 mg, flunitrazepam, 1 and 2 mg, as well as 0.9 g ethanol/kg body weight were investigated over a time period of 6 h in 12 healthy men. Blood samples were collected simultaneously with the test sessions to determine drug concentrations in plasma or blood. The ethanol dose caused the least performance impairment, followed by 10 mg diazepam. The most pronounced impairment was caused by 2 mg flunitrazepam, whereas 20 mg diazepam and 1 mg flunitrazepam caused intermediate impairment and were approximately equipotent on group level. Considerable interindividual differences with respect to maximal impairment following a particular drug treatment were observed, with poor correlation between individual maximal impairments and individual peak plasma concentrations of the drug. The maximal impairment in simple reaction time following the flunitrazepam treatments occurred earlier relative to the peak plasma concentration of the drug as compared to the diazepam treatments. This may indicate that acute tolerance develops differently for the two drugs. Springer-Verlag, 1992 Diazepam nationallicence Flunitrazepam nationallicence Ethanol nationallicence Psychomotor performance nationallicence Drug plasma concentration nationallicence Interindividual differences nationallicence Drug sensitivity nationallicence Ingum John National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut Bjørklund Roald Department of Physiology, National Institute of Occupational Health, N-Oslo, Norway aut Bjørneboe Anders National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut Christophersen Asbjørg National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut Dahlin Ellen National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut Mørland Jørg National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut Psychopharmacology Springer-Verlag 107/1(1992-05-01), 11-17 0033-3158 107:1<11 1992 107 213 https://doi.org/10.1007/BF02244959 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02244959 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ingum John National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut NATIONALLICENCE 700 1- Bjørklund Roald Department of Physiology, National Institute of Occupational Health, N-Oslo, Norway aut NATIONALLICENCE 700 1- Bjørneboe Anders National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut NATIONALLICENCE 700 1- Christophersen Asbjørg National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut NATIONALLICENCE 700 1- Dahlin Ellen National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut NATIONALLICENCE 700 1- Mørland Jørg National Institute of Forensic Toxicology, P.O. Box 16, Gaustad, N-0320, Oslo 3, Norway aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/1(1992-05-01), 11-17 0033-3158 107:1<11 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer