caa a22 4500 469120312 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245137 doi (NATIONALLICENCE)springer-10.1007/BF02245137 Different neuroleptics show common dose and time dependent effects in quantitative field potential analysis in freely moving rats [Elektronische Daten] [W. Dimpfel, M. Spüler, K. Wessel] Under the assumption that field potentials recorded from particular brain areas reflect the net balance of neurotransmitter activities, the dose- and time-dependent responses induced by intraperitoneal application of different neuroleptic drugs are quantified by spectral analysis of the electroencephalogram recorded from frontal cortex, hippocampus, striatum and reticular formation. The actions of haloperidol, chlorpromazine, clozapine, prothipendyl and thioridazine in general were characterized by increases of the spectral power in the alpha1 and beta range, at higher dosages also in the theta range. This observed pattern of changes is in line with the neuroleptic induced spectral changes reported in the literature for other animals and man. In the light of the already known effects of other psychoactive drugs on the frequency content of field potentials in the rat, it should now be possible to classify different drugs in terms of their clinical indication. With respect to the type of neurotransmitter control underlying the changes produced by various neuroleptics, it is quite obvious from the comparisons with the respective drug effects that dopamine-D1-receptor controlled transmission is not responsible for this action. On the basis of earlier findings a possible interaction between dopamin-D2 receptor or glutamatergic transmitter control is discussed. Springer-Verlag, 1992 Neuroleptics nationallicence Rat nationallicence Field potentials nationallicence Telemetry nationallicence Frequency analysis nationallicence Electroencephalogram nationallicence Dimpfel W. Pro Science Private Research Institute GmbH, W-6307, Linden, Federal Republic of Germany aut Spüler M. Pro Science Private Research Institute GmbH, W-6307, Linden, Federal Republic of Germany aut Wessel K. Asta Medica AG, W-6000, Frankfurt, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 195-202 0033-3158 107:2-3<195 1992 107 213 https://doi.org/10.1007/BF02245137 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245137 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dimpfel W. Pro Science Private Research Institute GmbH, W-6307, Linden, Federal Republic of Germany aut NATIONALLICENCE 700 1- Spüler M. Pro Science Private Research Institute GmbH, W-6307, Linden, Federal Republic of Germany aut NATIONALLICENCE 700 1- Wessel K. Asta Medica AG, W-6000, Frankfurt, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 195-202 0033-3158 107:2-3<195 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer