caa a22 4500 469120320 CHVBK 20180323133136.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245150 doi (NATIONALLICENCE)springer-10.1007/BF02245150 Sensitization to haloperidol-induced suppression of milk intake: effect of interdose interval [Elektronische Daten] [David Wolgin, Jacqueline Moore] The purpose of this study was to determine the effect of manipulating the interdose interval (IDI) on the suppression of milk intake induced by haloperidol (HAL). Groups of rats were given chronic injections of either HAL (0.625 mg/kg) or saline at IDIs of 1, 2, 7, or 14 days. Dose-response curves were determined at the conclusion of the chronic phase. The results indicated that injections of HAL given at IDIs of 1 or 2 days produced neither tolerance nor sensitization, whereas injections given at intervals of 7 or 14 days produced sensitization. Sensitization was also observed in the control groups, perhaps as a result of the intermittent schedule of HAL injections given during the dose-response tests. Sensitization to HAL was not accompanied by changes in sensitivity to amphetamine. The results of this experiment are consistent with those of other studies in showing that the behavioral effects of neuroleptics are strongly influenced by the schedule of injections. In addition, evidence is presented that sensitization to HAL-induced hypophagia is contingent on behavioral experience under the drug. Springer-Verlag, 1992 Haloperidol nationallicence Sensitization nationallicence Interdose interval nationallicence Milk intake nationallicence Amphetamine nationallicence Behavioral experience nationallicence Contingent sensitization nationallicence Wolgin David Institute for the Study of Alcohol and Drug Dependence, Department of Psychology, Florida Atlantic University, 33431, Boca Raton, FL, USA aut Moore Jacqueline Institute for the Study of Alcohol and Drug Dependence, Department of Psychology, Florida Atlantic University, 33431, Boca Raton, FL, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 290-296 0033-3158 107:2-3<290 1992 107 213 https://doi.org/10.1007/BF02245150 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245150 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wolgin David Institute for the Study of Alcohol and Drug Dependence, Department of Psychology, Florida Atlantic University, 33431, Boca Raton, FL, USA aut NATIONALLICENCE 700 1- Moore Jacqueline Institute for the Study of Alcohol and Drug Dependence, Department of Psychology, Florida Atlantic University, 33431, Boca Raton, FL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 290-296 0033-3158 107:2-3<290 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer