caa a22 4500 469120355 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245132 doi (NATIONALLICENCE)springer-10.1007/BF02245132 Behavioral screening for cognition enhancers: from indiscriminate to valid testing: Part I [Elektronische Daten] [Martin Sarter, Jim Hagan, Paul Dudchenko] Preclinical efforts to detect and characterize potential cognition enhancers appear to have been dominated by a strategy of demonstrating a wide variety of apparently beneficial behavioral effects with little attention given to the specific psychological mechanisms underlying behavioral enhancement. In particular, the question of whether or not behavioral facilitation is based on relevant mnemonic mechanisms and is independent of the stimulus properties and/or the motivational and attentional components of a task is not often considered. As a result, an overwhelming number of compounds have failed to produce the clinical effects predicted for them on the basis of preclinical research. The available data suggest that a more successful approach requires deductive research strategies rather than the indiscriminate accumulation of apparently beneficial effects in a variety of behavioral tasks and animal models. The first step towards such an approach is a systematic and rigorous evaluation of the different aspects of validity for the models most frequently used in preclinical research. It is concluded that a combination of good construct validity and good face validity represents a necessary condition for screening tests with predictive validity, and that the most popular paradigms fail to fulfil these criteria. Future screening programs for cognition enhancers will probably be characterized by a depreciation of "fast and dirty tests” in favor of approaches focussing on the validity of the effects of potential cognition enhancers. Springer-Verlag, 1992 Nootropics nationallicence Cognition enhancers nationallicence Dementia nationallicence Aging nationallicence Sarter Martin Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Hagan Jim Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Dudchenko Paul Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 144-159 0033-3158 107:2-3<144 1992 107 213 https://doi.org/10.1007/BF02245132 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245132 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sarter Martin Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Hagan Jim Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 700 1- Dudchenko Paul Department of Psychology, The Ohio State University, 27 Townshend Hall, 43210, Columbus, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 144-159 0033-3158 107:2-3<144 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 469120355 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer