caa a22 4500 469120371 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245145 doi (NATIONALLICENCE)springer-10.1007/BF02245145 Reinforcing and subjective effects of oral Δ9-THC and smoked marijuana in humans [Elektronische Daten] [L. Chait, James Zacny] The reinforcing and subjective effects of oral delta-9-tetrahydrocannabinol (THC) and smoked marijuana were studied in two groups of regular marijuana users. One group (N=10) was tested with smoked marijuana and the other (N=11) with oral THC. Reinforcing effects were measured with a discrete-trial choice procedure which allowed subjects to choose between the self-administration of active drug or placebo on two independent occasions. Subjective effects and heart rate were measured before and after drug administration. Smoked active marijuana was chosen over placebo on both choice occasions by all subjects. Similarly, oral THC was chosen over placebo on both occasions by all but one subject. Both active drug treatments produced qualitatively and quantitatively similar subjective effects, and both significantly increased heart rate, although the time course of effects differed substantially between the two treatments. The results demonstrate that both smoked marijuana and oral THC can serve as positive reinforcers in human subjects under laboratory conditions. The experimental paradigm used here should prove useful for identifying factors that influence the self-administration of marijuana and other cannabinoids by humans. Springer-Verlag, 1992 Human nationallicence Marijuana nationallicence THC nationallicence Subjective effects nationallicence Reinforcing effects nationallicence Self-administration nationallicence Route of administration nationallicence Chait L. Drug Abuse Research Center, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637, Chicago, IL, USA aut Zacny James Drug Abuse Research Center, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637, Chicago, IL, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 255-262 0033-3158 107:2-3<255 1992 107 213 https://doi.org/10.1007/BF02245145 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chait L. Drug Abuse Research Center, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Zacny James Drug Abuse Research Center, Department of Psychiatry, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 255-262 0033-3158 107:2-3<255 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer