caa a22 4500 46912038X CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245158 doi (NATIONALLICENCE)springer-10.1007/BF02245158 Effect of taurine on ethanol-induced changes in open-field locomotor activity [Elektronische Daten] [C. Aragon, L.-E. Trudeau, Z. Amit] In the present investigation we questioned whether taurine antagonized the effects of ethanol on motor activity measured in the open field. Ten minutes following simultaneous administration (IP) of ethanol (1.0, 1.5, 2.0 and 2.5 g/kg) or saline and taurine (30, 45 and 60 mg/kg) or saline, mice were placed in open field chambers and locomotor activity was measured during a 10 min testing period. A significant interaction was found between taurine and ethanol. Taurine-treated mice displayed lower motor excitation with the 1.0 g/kg dose of ethanol than the saline group treated with the same dose of ethanol. However at the 2.0 g/kg ethanol dose, taurine-treated mice demonstrated higher motor activity than the saline treated mice, once again, treated with the same dose of ethanol. No differences in blood ethanol levels were observed between the two groups. In a second study, taurine administration (30, 45 and 60 mg/kg) did not show any effect ond-amphetamine-induced enhancement of locomotor activity (1, 2, and 3 mg/kg). Data from this study demonstrated an interaction between taurine and ethanol in their effect on locomotor activity in the open field. Springer-Verlag, 1992 Ethanol nationallicence Taurine nationallicence Amphetamine nationallicence Locomotor nationallicence Rearing nationallicence Aragon C. Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut Trudeau L.-E Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut Amit Z. Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 337-340 0033-3158 107:2-3<337 1992 107 213 https://doi.org/10.1007/BF02245158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aragon C. Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Trudeau L.-E Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Amit Z. Center for Studies in Behavioral Neurobiology, Concordia University, 1455 De Maisonneuve Boulevard West, H3G 1M8, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 337-340 0033-3158 107:2-3<337 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer