caa a22 4500 469120436 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245138 doi (NATIONALLICENCE)springer-10.1007/BF02245138 Carey Robert Research and Development Service, VA Medical Center, and Department of Psychiatry, SUNY Health Sciences Center at Syracuse, 13210, Syracuse, NY, USA aut Pavlovian conditioning of l -dopa induced movement [Elektronische Daten] [Robert Carey] Using the unilateral 6-hydroxydopamine (6-OHDA) substantia nigra pars compacta (SNC) lesion rat model and a Pavlovian conditioning protocol, the present investigation determined that the contralateral rotation response induced by the antiparkinsonian dopaminergic drugl-dopa can become conditioned to exteroceptive test environment stimuli. Two non-drug conditioning tests indicated that contralateral rotation was elicited by the test environment without the presence ofl-dopa. This conditioned response had a rotation diameter profile that was qualitatively the same as thel-dopa induced contralateral rotation response. Additionally, drug tests with the combined dopaminergic receptor antagonists, SCH 23390 (0.1 mg/kg) and haloperidol (0.5 mg/kg), at doses sufficient to block spontaneous behavior andl-dopa (20 mg/kg)-induced rotation, revealed that the conditioned contralateral rotation response, unlikel-dopa-induced contralateral rotation, is not affected by D1/D2 receptor blockade. Thus, the conditoned stimuli of the test environment can elicit the contralateral rotation response even in animals rendered akinetic by D1/D2 antagonists. This activation of a conditioned dopaminergic drug response by the situational stimuli, independent of dopaminergic mechanisms, may, therefore, contribute to the untoward overstimulation clinical effects ofl-dopa through summation of conditioned and drug-induced effects. Furthermore, the use of conditioning procedures to elicit movement in akinetic animals may provide a new research methodology to investigate the phenomenon of paradoxical kinesia. Springer-Verlag, 1992 l -dopa nationallicence Dopamine nationallicence Pavlovian conditioning nationallicence Parkinson's disease nationallicence 6-Hydroxydopamine nationallicence Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 203-210 0033-3158 107:2-3<203 1992 107 213 https://doi.org/10.1007/BF02245138 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245138 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Carey Robert Research and Development Service, VA Medical Center, and Department of Psychiatry, SUNY Health Sciences Center at Syracuse, 13210, Syracuse, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 203-210 0033-3158 107:2-3<203 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer