caa a22 4500 469120452 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245135 doi (NATIONALLICENCE)springer-10.1007/BF02245135 PET analysis of alcohol interaction with the brain disposition of [11C]flumazenil [Elektronische Daten] [S. Pauli, S. Liljequist, L. Farde, C.-G. Swahn, C. Halldin, J.-E. Litton, G. Sedvall] Acute alcohol administration to rats has in preliminary studies been reported to drastically increase the binding of the benzodiazepine (BZ) receptor antagonist [3H]flumazenil (Ro 15-1788) to central BZ receptors. In the present study the effect of acute alcohol ingestion on the disposition of [11C]flumazenil in the human brain and plasma was examined by positron emission tomography (PET) in four healthy volunteers. Neocortex, cerebellum and pons (reference region) were delineated using X-ray computerized tomography (CT). Alcohol did not increase either total radioactivity uptake or specific [11C]flumazenil binding in neocortex or cerebellum. However, alcohol had a small but significant effect on [11C]flumazenil in arterial blood. After alcohol the plasma radioactivity peak was higher, more narrow and occurred earlier than in the control experiments. The present experiments contradict the view that alcohol directly affects central BZ receptor binding in man. Thus the dramatic increase of flumazenil binding in rat brain reported previously could not be observed in the human brain. Springer-Verlag, 1992 Positron emission tomography nationallicence Benzodiazepine receptors nationallicence Alcohol nationallicence Flumazenil nationallicence Human brain nationallicence Pauli S. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Liljequist S. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Farde L. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Swahn C.-G Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Halldin C. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Litton J.-E Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Sedvall G. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 180-185 0033-3158 107:2-3<180 1992 107 213 https://doi.org/10.1007/BF02245135 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245135 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pauli S. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Liljequist S. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Farde L. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Swahn C.-G Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Halldin C. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Litton J.-E Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 700 1- Sedvall G. Department of Psychiatry and Psychology, Karolinska Institute, S-10401, Stockholm, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 180-185 0033-3158 107:2-3<180 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer