caa a22 4500 469120460 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245155 doi (NATIONALLICENCE)springer-10.1007/BF02245155 Subjective and behavioral responses to intravenous fentanyl in healthy volunteers [Elektronische Daten] [James Zacny, J. Lance Lichtor, June Zaragoza, Harriet de Wit] Fentanyl is a mu opiate agonist which is occasionally abused by medical personnel who have ready access to the drug. We examined in healthy volunteers (N=13) the subjective and psychomotor-impairing effects of intravenous fentanyl (0-100 µg/70 kg). A randomized, placebo-controlled, crossover design was used in which subjects were injected with 0, 25 (N=6), 50 and 100 µg/70 kg fentanyl in a double-blind fashion. Subjects completed several questionnaires commonly used in abuse liability testing studies before drug injection and at periodic intervals for up to 3 h after drug injection. Subjects also completed several psychomotor tests at these times. Some aspects of psychomotor functioning (e.g., eye-hand coordination) were impaired by fentanyl. Fentanyl produced dose-related increases in ratings of "high” and "sedated,” but also tended to produce dysphoria and somatic symptomatology. Most subjects reported liking the effects of the two higher doses of fentanyl for at least a brief time after injection, but they varied widely in their liking ratings across the 3-h post-drug injection period. Despite the transient increases in liking ratings, fentanyl did not increase scores on a widely-used measure of drug-induced euphoria (morphine-benzedrine group scale of the Addiction Research Center Inventory). The present results suggest that some medical personnel who experiment with fentanyl may like it, and thus be at increased risk for abusing the drug in the future. Springer-Verlag, 1992 Fentanyl nationallicence Opiates nationallicence Subjective effects nationallicence Mood nationallicence Psychomotor performance nationallicence Humans nationallicence Zacny James Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut Lance Lichtor J. Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut Zaragoza June Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut de Wit Harriet Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 319-326 0033-3158 107:2-3<319 1992 107 213 https://doi.org/10.1007/BF02245155 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245155 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zacny James Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Lance Lichtor J. Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- Zaragoza June Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut NATIONALLICENCE 700 1- de Wit Harriet Department of Psychiatry, The University of Chicago, 5841 S. Maryland Avenue, Box 411, 60637, Chicago, IL, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 319-326 0033-3158 107:2-3<319 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer