caa a22 4500 469120487 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245172 doi (NATIONALLICENCE)springer-10.1007/BF02245172 Hypersensitivity to scopolamine in the elderly [Elektronische Daten] [Charles Flicker, Steven Ferris, Michael Serby] Scopolamine hydrobromide, 0.43 mg/70 kg, was administered by subcutaneous injection to ten young and ten elderly subjects. A comprehensive neuropsychological test battery was used to assess the effects of scopolamine, as compared to placebo, on cognitive function. As previously reported for this group of young subjects, scopolamine significantly impaired performance on tests of recent memory and visuospatial praxis. The same effects were observed in the elderly subjects, but the magnitude of the effects was much larger. The scopolamine injections produced significant psychomotor slowing in the elderly, whereas higher doses of the drug are required to produce this effect in young subjects. In both young and old subjects scopolamine failed to affect immediate memory, language function, object sorting, and the frequency of intrusion errors (although trends toward an effect were more apparent in the elderly). Remote memory, tested in the elderly only, was also unaffected. The results suggest that scopolamine's cognitive effects are quantitatively more pronounced in elderly subjects than young subjects, but that they are qualitatively similar and do not constitute a valid model for the cognitive dysfunction associated with Alzheimer's disease. Springer-Verlag, 1992 Scopolamine nationallicence Acetylcholine nationallicence Aging nationallicence Alzheimer's disease nationallicence Memory nationallicence Cognition nationallicence Flicker Charles Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Ferris Steven Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Serby Michael Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 437-441 0033-3158 107:2-3<437 1992 107 213 https://doi.org/10.1007/BF02245172 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245172 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Flicker Charles Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Ferris Steven Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 700 1- Serby Michael Department of Psychiatry (HN 314), New York University Medical Center, 550 First Avenue, 10016, New York, NY, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 437-441 0033-3158 107:2-3<437 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer