caa a22 4500 469120495 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245175 doi (NATIONALLICENCE)springer-10.1007/BF02245175 Haloperidol reduces ethanol-induced motor activity stimulation but not conditioned place preference [Elektronische Daten] [Fred Risinger, Shelly Dickinson, Christopher Cunningham] This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP) + ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms. Springer-Verlag, 1992 Haloperidol nationallicence Ethanol nationallicence Conditioned place aversion nationallicence Conditioned place preference nationallicence Inbred mice (DBA/2J) nationallicence Locomotor activity nationallicence Reward nationallicence Dopamine system nationallicence Risinger Fred Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut Dickinson Shelly Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut Cunningham Christopher Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 453-456 0033-3158 107:2-3<453 1992 107 213 https://doi.org/10.1007/BF02245175 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245175 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Risinger Fred Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Dickinson Shelly Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 700 1- Cunningham Christopher Department of Medical Psychology, The Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, 97201-3098, Portland, OR, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 453-456 0033-3158 107:2-3<453 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer