caa a22 4500 469120509 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245153 doi (NATIONALLICENCE)springer-10.1007/BF02245153 Benzodiazepine receptor mediation of behavioral effects of nitrous oxide in mice [Elektronische Daten] [R. Quock, D. Emmanouil, L. Vaughn, R. Pruhs] Nitrous oxide produces behavioral effects, the underlying mechanism of which is not known. In the mouse staircase test, exposure to nitrous oxide caused a reduction in rearing activity, an effect similar to that produced by benzodiazepines in this paradigm, when its opioid action on locomotion is blocked by naloxone. In this study, we tested whether effects of nitrous oxide might be mediated by benzodiazepine receptors, using chlordiazepoxide as a control. The abilities of nitrous oxide and chlordiazepoxide to reduce rearing were significantly attenuated in mice pretreated with the benzodiazepine receptor blocker flumazenil or rendered tolerant to benzodiazepines. These findings suggest an involvement of benzodiazepine receptors in mediation of certain behavioral effects of nitrous oxide. Springer-Verlag, 1992 Nitrous oxide nationallicence Chlordiazepoxide nationallicence Flumazenil nationallicence Naloxone nationallicence Benzodiazepine receptors nationallicence Staircase test nationallicence Mouse nationallicence Quock R. Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, 61107-1897, Rockford, IL, USA aut Emmanouil D. Department of Pediatric Dentistry, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut Vaughn L. Department of Basic Sciences, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut Pruhs R. Department of Pediatric Dentistry, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 310-314 0033-3158 107:2-3<310 1992 107 213 https://doi.org/10.1007/BF02245153 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245153 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quock R. Department of Biomedical Sciences, University of Illinois College of Medicine at Rockford, 1601 Parkview Avenue, 61107-1897, Rockford, IL, USA aut NATIONALLICENCE 700 1- Emmanouil D. Department of Pediatric Dentistry, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Vaughn L. Department of Basic Sciences, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut NATIONALLICENCE 700 1- Pruhs R. Department of Pediatric Dentistry, Marquette University School of Dentistry, 53233-2188, Milwaukee, WI, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 310-314 0033-3158 107:2-3<310 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer