caa a22 4500 469120517 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245160 doi (NATIONALLICENCE)springer-10.1007/BF02245160 Like diazepam, CL 218,872, a selective ligand for the benzodiazepine ω1 receptor subtype, impairs place learning in the Morris water maze [Elektronische Daten] [Robert McNamara, Ronald Skelton] The sedative, anxiolytic, and amnesic effects of diazepam were compared to those of CL 218,872, a triazolopyridazine that has a preferential affinity for the benzodiazepine ω1 receptor subtype. Spontaneous locomotion was assessed using a running wheel, anxiety was assessed using an open-field divided into central and peripheral areas (thigmotaxis), and amnesia was assessed using the Morris water maze. It was found that CL 218,872, like diazepam, depressed spontaneous locomotion, reduced anxiety, and impaired place learning in a dose-dependent manner. Flumazenil, a benzodiazepine receptor antagonist with a similar affinity for both ω1 and ω2 subtypes, reversed all of the effects of diazepam and antagonized the anxiolytic and amnesic effects, and some but not all of the sedative effects of CL 218,872. These results suggest that the selective activation of the ω1 receptor subtype by CL 218,872 is sufficient to produce sedation, anxiolysis, and amnesia in a manner similar to that produced by the coactivation of both the ω1 and ω2 receptor subtypes with diazepam. Springer-Verlag, 1992 CL 218,872 nationallicence Diazepam nationallicence Triazolopyridazine nationallicence Benzodiazepine nationallicence Flumazenil nationallicence Spontaneous locomotion nationallicence Thigmotaxis nationallicence Place learning nationallicence Cue learning nationallicence Morris water maze nationallicence Sedation nationallicence Anxiety nationallicence Amnesia nationallicence Rat nationallicence McNamara Robert Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B. C., Canada aut Skelton Ronald Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B. C., Canada aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 347-351 0033-3158 107:2-3<347 1992 107 213 https://doi.org/10.1007/BF02245160 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245160 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McNamara Robert Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B. C., Canada aut NATIONALLICENCE 700 1- Skelton Ronald Department of Psychology, University of Victoria, P.O. BOX 3050, V8W 3P5, Victoria, B. C., Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 347-351 0033-3158 107:2-3<347 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer