caa a22 4500 469120525 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245169 doi (NATIONALLICENCE)springer-10.1007/BF02245169 The roman strains of rats as a psychogenetic tool for pharmacological investigation of working memory: example with RU 41656 [Elektronische Daten] [F. Willig, D. Van de Velde, J. Laurent, M. M'Harzi, J. Delacour] This study examined the effects of RU 41656, a dopaminergic D2 agonist, on the differential working memory performances and on the differential activities of the neurochemical systems of the Roman high (RHA) and Roman low (RLA) avoidance strains of rats. Compared with RLA, RHA performed worse in three tests of working memory (spontaneous alternation, radial maze and object recognition) and had higher levels of exploratory locomotor activity. Hippocampal and frontal cortex choline acetyltransferase (ChAT) activities were loer in RHA. Frontal cortex DA and DOPAC levels, hippocampal and striatal 5-HT and NA levels were higher in RHA. RU 41656 induced a significant improvement in working memory performance of RHA, whereas in RLA it had no effect. It decreased exploratory locomotor activity in both strains. ChAT activity in hippocampus was not affected by RU 41656 in either strain, whereas in frontal cortex it was increased in RHA but not in RLA. Hippocampal NA levels were decreased by RU 41656 in RHA but not in RLA. These results confirm previous data concerning the promnesic effect of RU 41656 and extend the finding that the Roman strains are a psychogenetic model for the behavioural, neurochemical and psychopharmacological study of the working memory in rats. Springer-Verlag, 1992 Roman strains nationallicence Psychogenetic selection nationallicence Working memory nationallicence Exploratory behaviour nationallicence Spontaneous alternation nationallicence Radial maze nationallicence Object recognition nationallicence Acetylcholine nationallicence Dopamine nationallicence Noradrenaline nationallicence Serotonin nationallicence Hippocampus nationallicence Frontal cortex nationallicence Striatum nationallicence RU 41656 nationallicence D2 agonist nationallicence Willig F. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut Van de Velde D. Département de Pharmacologie-Neurobiologie, Centre de Recherches Roussel-Uclaf, 111 route de Noisy, F-93230, Romainville, France aut Laurent J. Département de Pharmacologie-Neurobiologie, Centre de Recherches Roussel-Uclaf, 111 route de Noisy, F-93230, Romainville, France aut M'Harzi M. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut Delacour J. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 415-424 0033-3158 107:2-3<415 1992 107 213 https://doi.org/10.1007/BF02245169 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245169 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Willig F. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut NATIONALLICENCE 700 1- Van de Velde D. Département de Pharmacologie-Neurobiologie, Centre de Recherches Roussel-Uclaf, 111 route de Noisy, F-93230, Romainville, France aut NATIONALLICENCE 700 1- Laurent J. Département de Pharmacologie-Neurobiologie, Centre de Recherches Roussel-Uclaf, 111 route de Noisy, F-93230, Romainville, France aut NATIONALLICENCE 700 1- M'Harzi M. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut NATIONALLICENCE 700 1- Delacour J. Laboratoire de Psychophysiologie, Université Paris 7, 7 Quai Saint-Bernard, F-75251, Paris Cedex 05, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 415-424 0033-3158 107:2-3<415 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer