caa a22 4500 469120533 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245171 doi (NATIONALLICENCE)springer-10.1007/BF02245171 Modulation of MK-801 response by dopaminergic agents in mice [Elektronische Daten] [Anita Verma, S. Kulkarni] Various doses of the non-competitive N-methyl-d-aspartate (NMDA) receptor antagonists, MK-801 (0.1-0.5 mg/kg) and ketamine (2.5-10 mg/kg), produced a dose-dependent increase in stereotypic behaviour in naive mice. MK-801 (0.1 mg/kg) and ketamine (2.5 mg/kg) potentiated the stereotypic response of apomorphine (0.1-0.5 mg/kg) in mice pretreated with reserpine (5 mg/kg, 24 h prior) and alpha-methyl-p-tyrosine (150 mg/kg, 1 h prior) but not in naive mice. SKF 38393, a D1 dopamine agonist, enhanced whereas B-HT 920, a D2 dopamine agonist, reduced the stereotypic response of MK-801 in naive mice. The response of MK-801 was blocked by pretreatment with haloperidol (0.5 mg/kg), molindone (2.5 mg/kg), clozapine (7.5 mg/kg) and SCH 23390 (0.1 mg/kg). The present data suggest involvement of endogenous DA transmission in the stimulant action of non-competitive NMDA antagonists in mice. Dopamine D1 and D2 receptor stimulation, respectively, exert opposing effects on the behavioural expression of MK-801 in mice. Springer-Verlag, 1992 Dopamine nationallicence MK-801 nationallicence Ketamine nationallicence Stereotypy nationallicence Apomorphine nationallicence SKF 38393 nationallicence Verma Anita Pharmacology Division, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India aut Kulkarni S. Pharmacology Division, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 431-436 0033-3158 107:2-3<431 1992 107 213 https://doi.org/10.1007/BF02245171 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245171 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Verma Anita Pharmacology Division, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 700 1- Kulkarni S. Pharmacology Division, Department of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 431-436 0033-3158 107:2-3<431 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer