caa a22 4500 469120584 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245159 doi (NATIONALLICENCE)springer-10.1007/BF02245159 Involvement of dopamine receptor subtypes in mouse thermoregulation [Elektronische Daten] [M. Zarrindast, S. Tabatabai] The effects of dopamine agonists on core body temperature (BT) were tested in mice. Apomorphine (APO) reduced BT of the mice dose dependently. The response was inhibited by the D-2 antagonist sulpiride, but not by the D-1 antagonist SCH 23390. The D-2 agonist quinpirole also decreased BT and this was prevented by sulpiride pretreatment. Administration of the D-1 agonist SKF 38393 increased BT. This hyperthermia was decreased by SCH 23390 pretreatment. In reserpinized animals, APO caused a dose-related increase in BT. The hyperthermic response of the drug was abolished in animals pretreated with a combination of sulpiride with SCH 23390, but not by single administration of sulpiride or SCH 23390. Quinpirole and SKF 38393 caused hyperthermia in reserpinized mice. The response was decreased in animals pretreated with sulpiride or SCH 23390, respectively. BT of the intact mice was decreased, while that of reserpinized animals was increased by SCH 23390 but not by sulpiride pretreatment. It is concluded that the presynaptic dopamine neurons are involved in hypothermia, while both post-synaptic D-1 and D-2 dopamine receptors may mediated the hyperthermia induced by dopaminergic agents. Springer-Verlag, 1992 Core body temperature nationallicence Apomorphine nationallicence Quinpirole nationallicence SKF 38393 nationallicence Sulpiride nationallicence SCH 23390 nationallicence Reserpine and mice nationallicence Zarrindast M. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Tabatabai S. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 341-346 0033-3158 107:2-3<341 1992 107 213 https://doi.org/10.1007/BF02245159 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245159 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zarrindast M. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 700 1- Tabatabai S. Department of Pharmacology, Medical Faculty, University of Tehran, Tehran, Iran aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 341-346 0033-3158 107:2-3<341 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer