caa a22 4500 469120606 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245170 doi (NATIONALLICENCE)springer-10.1007/BF02245170 Abolition of latent inhibition by a single 5 mg dose of d -amphetamine in man [Elektronische Daten] [N. Gray, A. Pickering, D. Hemsley, S. Dawling, J. Gray] The performance of healthy volunteer subjects on an auditory latent inhibition (LI) paradigm was assessed following administration of a single oral dose ofd-amphetamine or placebo. It was predicted that a low (5 mg), but not a high (10 mg), dose ofd-amphetamine would disrupt LI. The prediction was supported with left ear presentation of the preexposed stimulus only. When the preexposed stimulus was presented to the right ear the predicted pattern of findings was not obtained. It is concluded that the dopaminergic system is involved in the mediation of LI in man and it is speculated that the interaction between amphetamine dose and ear of presentation of the preexposed stimulus may reflect normally occurring dopaminergic hemisphere asymmetry. Springer-Verlag, 1992 Latent inhibition nationallicence d -Amphetamine nationallicence Schizophrenia nationallicence Attention nationallicence Man nationallicence Lateralisation of function nationallicence Gray N. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut Pickering A. Department of Psychology, St. George's Hospital Medical School, SW17 ORE, London, UK aut Hemsley D. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut Dawling S. National Poisons Unit, Guy's and Lewisham Trust, Avonley Road, SE14 5ER, London, UK aut Gray J. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 425-430 0033-3158 107:2-3<425 1992 107 213 https://doi.org/10.1007/BF02245170 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245170 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gray N. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Pickering A. Department of Psychology, St. George's Hospital Medical School, SW17 ORE, London, UK aut NATIONALLICENCE 700 1- Hemsley D. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut NATIONALLICENCE 700 1- Dawling S. National Poisons Unit, Guy's and Lewisham Trust, Avonley Road, SE14 5ER, London, UK aut NATIONALLICENCE 700 1- Gray J. Department of Psychology, Institute of Psychiatry, SE5 8AF, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 425-430 0033-3158 107:2-3<425 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer