caa a22 4500 469120614 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245162 doi (NATIONALLICENCE)springer-10.1007/BF02245162 Partial reversal of fluoxetine anorexia by the 5-HT antagonist metergoline [Elektronische Daten] [Michelle Lee, Peter Clifton] Experiment 1 showed that the reduction of intake produced by 5 or 10 mg/kg fluoxetine in rats eating either a solid or a liquid meal was partially antagonised by 1 mg/kg of the 5HT1/5HT2 antagonist metergoline but not by 1 mg/kg of the 5HT2 antagonist ketanserin. Experiment 2 examined the meal patterning of rats given 5 mg/kg fluoxetine and 1 mg/kg metergoline. Fluoxetine alone increased the latency to feed, reduced meal size and shifted the inter-pellet interval (IPI) distribution to the right. Metergoline alone had little immediate effect on food intake or other feeding parameters but partially reversed the reduction of food intake produced by fluoxetine. There was a complete reversal of the increased latency to feed and a partial reversal of the depression of meal size. However, the rightward shift of the IPI distribution caused by fluoxetine, which indicated a depression of feeding rate, was more pronounced after combined treatment. We conclude that fluoxetine reduces food intake by enhancing satiety through a serotonergic dependent mechanism but reduces feeding rate through a separate mechanism, whose neurochemical basis remains to be established. Springer-Verlag, 1992 Fluoxetine nationallicence Metergoline nationallicence Ketanserin nationallicence Anorexia nationallicence Feeding rate nationallicence Lee Michelle Laboratory of Experimental Psychology, University of Sussex, BN1 9QG, Brighton, Sussex, UK aut Clifton Peter Laboratory of Experimental Psychology, University of Sussex, BN1 9QG, Brighton, Sussex, UK aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 359-364 0033-3158 107:2-3<359 1992 107 213 https://doi.org/10.1007/BF02245162 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245162 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Michelle Laboratory of Experimental Psychology, University of Sussex, BN1 9QG, Brighton, Sussex, UK aut NATIONALLICENCE 700 1- Clifton Peter Laboratory of Experimental Psychology, University of Sussex, BN1 9QG, Brighton, Sussex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 359-364 0033-3158 107:2-3<359 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer