caa a22 4500 469120622 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245151 doi (NATIONALLICENCE)springer-10.1007/BF02245151 Heightened aggressive behavior during morphine withdrawal: effects of d -amphetamine [Elektronische Daten] [J. Tidey, K. Miczek] The morphine withdrawal syndrome is composed of profound short- and long-term changes in autonomic, somato-motor and affective functions. In mice, morphine withdrawal produces heightened aggressive behavior and alterations in motor behavior; however, it is unclear whether these changes in behavior occur in unison and are dependent on a common mechanism or occur independently. In order to characterize the morphine withdrawal syndrome in mice, male Swiss-Webster mice were housed with female partners for 3-4 weeks before being implanted subcutaneously with morphine or placebo pellets. The pellets were removed 72 h after implantation and behavioral measurements were conducted 5, 48 and 96 h after pellet removal. During these tests, mice receivedd-amphetamine (0.3-10 mg/kg) or saline after which they were assessed for changes in motor behavior and for changes in aggressive behavior while confronting a group-housed male "intruder”. In morphine-withdrawn mice, frequency of attack behavior was increased by approximately 30% and this effect persisted for at least 4 days. In contrast, explosive jumping was increased and walking and rearing were greatly decreased at the onset of the withdrawal period but declined within the first 24 h and returned to control levels within 48 h of pellet removal.d-Amphetamine maintained the elevated level of aggressive behavior and sharply increased locomotion in morphine-withdrawn mice; in placebo-pelleted mice,d-amphetamine dose-dependently decreased aggressive behaviors while increasing locomotion. The differential time course and the differential modification byd-amphetamine suggest that heightened aggressive behavior is a long-lasting consequence of morphine-withdrawal based on separate mechanisms than the short-lived alterations in motor activity. Springer-Verlag, 1992 Amphetamine nationallicence Aggression nationallicence Opiates nationallicence Withdrawal nationallicence Locomotion nationallicence Motor activity nationallicence Tidey J. Department of Psychology, Research Building, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut Miczek K. Department of Psychology, Research Building, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 297-302 0033-3158 107:2-3<297 1992 107 213 https://doi.org/10.1007/BF02245151 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245151 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tidey J. Department of Psychology, Research Building, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut NATIONALLICENCE 700 1- Miczek K. Department of Psychology, Research Building, Tufts University, 490 Boston Avenue, 02155, Medford, MA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 297-302 0033-3158 107:2-3<297 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer