caa a22 4500 469120630 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245165 doi (NATIONALLICENCE)springer-10.1007/BF02245165 Kennett G. SmithKline Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, CM19 5AD, Harlow, Essex, UK aut 5-HT1C receptor antagonists have anxiolytic-like actions in the rat social interaction model [Elektronische Daten] [G. Kennett] The effects of a range of 5-HT receptor antagonists were examined in an animal model of anxiety — the social interaction test. Six antagonists with high affinity for 5-HT1C receptors; mianserin, (+) mianserin, 1-naphthyl piperazine, ICI 169 369, pizotifen and LY 53857 all increased the time spent in active social interaction by pairs of weight-matched rats under high light unfamiliar conditions. As locomotion was only increased by 1-NP and then only at high doses, the effect of the drugs is consistent with anxiolysis. These properties were shared by the benzodiazepine anxiolytic chlordiazepoxide but not by the specific 5-HT2 antagonists ketanserin and altanserin, nor by the 5-HT1A and 5-HT1B antagonists cyanopindolol and pindolol. Similarly, neither the adrenergic α2 antagonist idazoxan, the α2 antagonist and putative 5-HT1D partial agonist yohimbine nor the H1 antagonist mepyramine had any significant effect. Since (+)mianserin, LY 53857 and ICI 169 369 at least have low affinity for 5-HT3 receptors these receptors are also unlikely to be involved. The results therefore imply that the observed anxiolytic effects of the drugs are likely to be mediated by 5-HT1C receptor blockade. Springer-Verlag, 1992 Anxiety nationallicence 5-HT nationallicence 5-HT1C receptors nationallicence Social interaction nationallicence Mianserin nationallicence Benzodiazepines nationallicence Ketanserin nationallicence Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 379-384 0033-3158 107:2-3<379 1992 107 213 https://doi.org/10.1007/BF02245165 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245165 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Kennett G. SmithKline Beecham Pharmaceuticals, Coldharbour Road, The Pinnacles, CM19 5AD, Harlow, Essex, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 379-384 0033-3158 107:2-3<379 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer