caa a22 4500 469120649 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245157 doi (NATIONALLICENCE)springer-10.1007/BF02245157 Amphetamine or haloperidol 2 weeks earlier antagonized the plasma corticosterone response to amphetamine; evidence for the stressful/foreign nature of drugs [Elektronische Daten] [Seymour Antelman, Anthony Caggiula, Steven Knopf, Donna Kocan, David Edwards] We inquired whether a single exposure to amphetamine (AM) or haloperidol (HALO) could modify the plasma corticosterone (CORT) response to a second injection of AM 2 weeks later. Male rats were injected with 4 mg/kgd-AM sulfate and tested for water intake for 5 h before sacrifice. Overall, AM induced water intake but none of the pretreatments altered this effect. By contrast, preexposure to AM, HALO or its vehicle 2 weeks earlier prevented the elevation of plasma CORT obtained when AM was administered without pretreatment. A combined pretreatment of HALO or its vehicle with AM produced an even greater blockade of AM-induced CORT elevation. Manipulations which prevented AM-induced drinking reduced the effectiveness of AM pretreatment in attenuating AM-induced elevation in CORT, suggesting that the pretreatment may have been sensitizing the effectiveness of a coping response — drinking — in reducing the CORT effect. Our findings also indicate that a dopamine agonist (AM), a dopamine antagonist (HALO) and a nonspecific stressor (acidic vehicle) can all induce the same, long-lasting action on CORT. This strongly suggests that the effects of AM and HALO in this instance cannot be explained in terms of their pharmacological actions, which are opposite to one another, but instead relate to their properties as stressful/foreign agents to the organism. Springer-Verlag, 1992 Amphetamine nationallicence Haloperidol nationallicence Stress nationallicence Sensitization nationallicence Corticosterone nationallicence Antelman Seymour Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut Caggiula Anthony Department of Psychology, School of Dental Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Knopf Steven Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut Kocan Donna Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut Edwards David Department of Physiology-Pharmacology, School of Dental Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 331-336 0033-3158 107:2-3<331 1992 107 213 https://doi.org/10.1007/BF02245157 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245157 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antelman Seymour Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut NATIONALLICENCE 700 1- Caggiula Anthony Department of Psychology, School of Dental Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Knopf Steven Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut NATIONALLICENCE 700 1- Kocan Donna Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, USA aut NATIONALLICENCE 700 1- Edwards David Department of Physiology-Pharmacology, School of Dental Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 331-336 0033-3158 107:2-3<331 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer