caa a22 4500 469120657 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245140 doi (NATIONALLICENCE)springer-10.1007/BF02245140 Effects of quinpirole and SKF 38393 alone and in combination in squirrel monkeys trained to discriminate cocaine [Elektronische Daten] [J. Katz, J. Witkin] The present study was designed to assess the behavioral similarity of the effects of prototype dopamine receptor-subtype selective agonists and cocaine. Squirrel monkeys (N=4) were trained with food reinforcement to press one of two levers after administration of IV cocaine (0.3 mg/kg) or the other lever after saline. After training, IV cocaine produced reliable responding on the cocaine lever (>98%), whereas saline produced reliable responding on the alternate lever (>98%). The D2 agonist, quinpirole (0.003-1.0 mg/kg, IM), produced dose-related increases in cocaine-appropriate responding, with maximal effects of 62%. When delivered IV, quinpirole (0.01-0.17 mg/kg) was approximately twice as potent, but no more effective. The D1 agonist, SKF 38393 (0.3-30.0 mg/kg, IM or 3.0-17.0 mg/kg, IV) failed to produce any significant cocaine-appropriate responding. Further, pretreatment with SKF 38393 (either 0.3 or 10.0 mg/kg, IM) did not significantly alter the the quinpirole (0.01-1.0 mg/kg, IM) dose-effect curve. The effects of these drugs differ from those previously reported in rats, suggesting a species difference that may be of importance in evaluating the behavioral pharmacology of cocaine. Springer-Verlag, 1992 Cocaine nationallicence Quinpirole nationallicence SKF 38393 nationallicence D1 agonist nationallicence D2 agonist nationallicence Drug interactions nationallicence Route of administration nationallicence Discriminative-stimulus effects nationallicence Behavior nationallicence Squirrel monkeys nationallicence Katz J. Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O.Box 5180, 21224, Baltimore, MD, USA aut Witkin J. Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O.Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 217-220 0033-3158 107:2-3<217 1992 107 213 https://doi.org/10.1007/BF02245140 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245140 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katz J. Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O.Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Witkin J. Psychobiology Laboratory, Preclinical Pharmacology Branch, NIDA Addiction Research Center, P.O.Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 217-220 0033-3158 107:2-3<217 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer