caa a22 4500 469120665 CHVBK 20180323133137.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245163 doi (NATIONALLICENCE)springer-10.1007/BF02245163 Sodium pentobarbital: sensory and associative effects in classical conditioning of the rabbit nictitating membrane response [Elektronische Daten] [Ping Chen, M. Ghoneim, I. Gormezano] Four experiments were conducted to determine the effects of sodium pentobarbital (0, 3, 9, and 15 mg/kg) on the acquisition of the rabbit's classically conditioned nictitating membrane response (NMR) and to determine the locus of the drug's effects on sensory, motor, associative, and nonassociative processes. In experiment 1, classical conditioning of the NMR was accomplished by pairing tone and light conditioned stimuli (CSs) with paraorbital shock as the unconditioned stimulus (US). The experiment revealed that pentobarbital retarded the acquisition of conditioned responses (CRs) to both tone and light CSs. Experiment 2, employing unpaired CS, UCS presentations, indicated small but significant drug effects on NMR base rate and nonassociative NMRs to the CS. Experiment 3 revealed no significant drug effect on the psychophysical functions relating UCS intensity to UCR frequency or amplitude, nor on the UCS intensity threshold for eliciting UCRs. On the other hand, in experiment 4, the drug significantly impaired CR frequency over an extended range of CS intensities and raised CS intensity threshold. It was concluded that pentobarbital's attenuation of CS intensity also operated to impair CR acquisition. Springer-Verlag, 1992 Sodium pentobarbital nationallicence Classical conditioning nationallicence Rabbit nationallicence Nictitating membrane response nationallicence Learning nationallicence Chen Ping Department of Anesthesia, The University of Iowa, 52242, Iowa City, IA, USA aut Ghoneim M. Department of Anesthesia, The University of Iowa, 52242, Iowa City, IA, USA aut Gormezano I. Department of Psychology, The University of Iowa, 52242, Iowa City, IA, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 365-372 0033-3158 107:2-3<365 1992 107 213 https://doi.org/10.1007/BF02245163 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245163 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Ping Department of Anesthesia, The University of Iowa, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Ghoneim M. Department of Anesthesia, The University of Iowa, 52242, Iowa City, IA, USA aut NATIONALLICENCE 700 1- Gormezano I. Department of Psychology, The University of Iowa, 52242, Iowa City, IA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 365-372 0033-3158 107:2-3<365 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer