caa a22 4500 469120703 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245148 doi (NATIONALLICENCE)springer-10.1007/BF02245148 Locomotor-activating effects of the D2 agonist bromocriptine show environment-specific sensitization following repeated injections [Elektronische Daten] [Diane Hoffman, Roy Wise] Biphasic effects of bromocriptine (2.0, 5.0, 10.0, and 20.0 mg/kg IP) on locomotion were quantified in photocell activity boxes in rats. Following early suppression of activity, bromocriptine produced a clear, dose-dependent increase in locomotion that lasted several hours. When a low dose of bromocriptine (5.0 mg/kg) was administered daily over a 3-week period, the locomotor-activating effects of the drug showed progressive enhancement over days. The sensitization was environment specific; rats administered bromocriptine six times in the home cage showed no sign of a sensitized response to bromocriptine when subsequently tested in the activity box. Thus, selective stimulation of D2 receptors stimulates locomotion and sensitizes animals to subsequent injections, just as do the indirect-acting dopamine agonists cocaine and amphetamine. Springer-Verlag, 1992 Bromocriptine nationallicence Conditioning nationallicence D2 receptors nationallicence Dopamine nationallicence Locomotion nationallicence Sensitization nationallicence Hoffman Diane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard W., H3G 1M8, Montreal, Canada aut Wise Roy Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard W., H3G 1M8, Montreal, Canada aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 277-284 0033-3158 107:2-3<277 1992 107 213 https://doi.org/10.1007/BF02245148 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245148 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hoffman Diane Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard W., H3G 1M8, Montreal, Canada aut NATIONALLICENCE 700 1- Wise Roy Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, 1455 de Maisonneuve Boulevard W., H3G 1M8, Montreal, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 277-284 0033-3158 107:2-3<277 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer