caa a22 4500 469120746 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245149 doi (NATIONALLICENCE)springer-10.1007/BF02245149 The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine [Elektronische Daten] [William Corrigall, Keith Franklin, Kathleen Coen, Paul Clarke] Rats were trained to self-administer nicotine on a fixed-ratio schedule of reinforcement. Infusion of the nicotinic antagonist chlorisondamine into the cerebral ventricles produced a sustained reduction in nicotine self-administration compared to vehicle-treated controls. Lesions of the mesolimbic dopamine system were produced by microinfusion of 6-hydroxydopamine into the nucleus accumbens. Following production of the lesions, nicotine self-administration was markedly reduced for the 3-week test period; motor impairment did not appear to be responsible. Post mortem analysis of brain tissue showed that the lesion produced a pronounced decrease in dopamine content of the nucleus accumbens and the olfactory tubercle, and a small depletion in the striatum. These data demonstrate that the reinforcing effects of nicotine occur within the central nervous system, and that the mesolimbic dopamine projection plays an important role in these effects. Springer-Verlag, 1992 Nicotine nationallicence Mesolimbic dopamine nationallicence Reinforcement nationallicence Nucleus accumbens nationallicence Dopamine nationallicence 6-Hydroxydopamine nationallicence Corrigall William Neurobiology Section, Addiction Research Foundation, M5S 2S1, Toronto, Ontario, Canada aut Franklin Keith Department of Psychology, McGill University, H3A 1B1, Montreal, Quebec, Canada aut Coen Kathleen Neurobiology Section, Addiction Research Foundation, M5S 2S1, Toronto, Ontario, Canada aut Clarke Paul Department of Pharmacology and Therapeutics, McGill University, H3G 1Y6, Montreal, Quebec, Canada aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 285-289 0033-3158 107:2-3<285 1992 107 213 https://doi.org/10.1007/BF02245149 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245149 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Corrigall William Neurobiology Section, Addiction Research Foundation, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Franklin Keith Department of Psychology, McGill University, H3A 1B1, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Coen Kathleen Neurobiology Section, Addiction Research Foundation, M5S 2S1, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Clarke Paul Department of Pharmacology and Therapeutics, McGill University, H3G 1Y6, Montreal, Quebec, Canada aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 285-289 0033-3158 107:2-3<285 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer