caa a22 4500 469120762 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245154 doi (NATIONALLICENCE)springer-10.1007/BF02245154 Reinforcing effects of enantiomers of N,N-dimethylamphetamine in squirrel monkeys [Elektronische Daten] [Jonathan Katz, George Ricaurte, Jeffrey Witkin] Reinforcing effects of the (+)- and (-)-enantiomers of N,N-dimethylamphetamine, a drug that is abused in humans, were studied in squirrel monkeys(Siamiri sciureus) trained under schedules of intermittent cocaine reinforcement. During training, each 30th response produced an injection of cocaine (fixed-ratio schedule), which was followed by a 1-min period during which lights were out and responses had no scheduled consequences (timeout). Sessions in which cocaine injections were scheduled alternated in an irregular sequence with sessions in which saline injections were scheduled. After training, response rates were well maintained by cocaine (response rates approximated 1.4 responses per second) but occurred relatively infrequently during sessions in which saline was injected (response rates approximated 0.3 responses per second). Doses of 10 to 56 µg/kg/injection of (+)-N,N-dimethylamphetamine maintained rates of responding significantly higher than those maintained by saline. The (-)-enantiomer did not maintain rates of responding that were higher than those maintained by saline when tested at doses up to 100 µg/kg/injection. These findings support previous results indicating that N,N-dimethylamphetamine will function as a reinforcer in laboratory animals. Further, they suggest that the significant reinforcing activity of this drug is restricted to the (+)-enantiomer. Springer-Verlag, 1992 Reinforcing effects of drugs nationallicence Drug self administration nationallicence N,N-dimethylamphetamine nationallicence Stereoisomers nationallicence Abuse liability assessment nationallicence Fixed-ratio schedule nationallicence Squirrel monkeys nationallicence Katz Jonathan Psychobiology Laboratory, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Ricaurte George Department of Neurology, Johns Hopkins University School of Medicine, 21224, Baltimore, MD, USA aut Witkin Jeffrey Psychobiology Laboratory, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 315-318 0033-3158 107:2-3<315 1992 107 213 https://doi.org/10.1007/BF02245154 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245154 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Katz Jonathan Psychobiology Laboratory, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Ricaurte George Department of Neurology, Johns Hopkins University School of Medicine, 21224, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Witkin Jeffrey Psychobiology Laboratory, NIDA Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/2-3(1992-06-01), 315-318 0033-3158 107:2-3<315 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer