caa a22 4500 469120770 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245268 doi (NATIONALLICENCE)springer-10.1007/BF02245268 Effects of alprazolam and imipramine on parasympathetic cardiac control in patients with generalized anxiety disorder [Elektronische Daten] [Daniel McLeod, Rudolf Hoehn-Saric, Stephen Porges, Wesley Zimmerli] A noninvasive measure was used to assess the effects of alprazolam, imipramine and placebo on parasympathetic (vagal) cardiac control following 6-weeks of medication in patients with generalized anxiety disorder. Flexible dosage at therapeutic levels resulted in increased heart rate and blood pressure and in decreased cardiac vagal control in patients receiving imipramine but not alprazolam or placebo. About 50% of the variance in heart rate changes and changes in mean arterial blood pressure following treatment with imipramine could be accounted for by changes in cardiac vagal control. Decreased cardiac vagal control can now be added to the list of cardiovascular changes seen following several weeks of treatment with imipramine. Springer-Verlag, 1992 Imipramine nationallicence Alprazolam nationallicence Heart rate nationallicence Blood pressure nationallicence Cardiac vagal control nationallicence Respiratory sinus arrhythmia nationallicence Human subjects nationallicence Generalized anxiety disorder nationallicence McLeod Daniel Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut Hoehn-Saric Rudolf Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut Porges Stephen Institute for Child Study, University of Maryland, 3304 Benjamin Building, 20742, College Park, MD, USA aut Zimmerli Wesley Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 535-540 0033-3158 107:4<535 1992 107 213 https://doi.org/10.1007/BF02245268 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245268 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McLeod Daniel Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Hoehn-Saric Rudolf Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Porges Stephen Institute for Child Study, University of Maryland, 3304 Benjamin Building, 20742, College Park, MD, USA aut NATIONALLICENCE 700 1- Zimmerli Wesley Department of Psychiatry, The Johns Hopkins University School of Medicine, The Johns Hopkins Hospital, Meyer 144, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 535-540 0033-3158 107:4<535 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer