caa a22 4500 469120827 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245272 doi (NATIONALLICENCE)springer-10.1007/BF02245272 Effects of trazodone on EEG sleep and clinical state in major depression [Elektronische Daten] [A. van Bemmel, R. Havermans, R. van Diest] The effects of the antidepressant trazodone on clinical state and on EEG sleep in eight outpatients with a major depressive disorder were investigated in a single blind study. A medication period of 5 weeks was preceded and followed by one week placebo treatment. Five subjects showed a positive treatment response. Trazodone did not influence sleep continuity and slow wave sleep, but did suppress REM sleep significantly. A significant increase of REM sleep latency was also found. These results are in contrast with earlier reports on trazodone's effects on EEG sleep but are in accordance with the general finding that antidepressants influence REM sleep characteristics without necessarily affecting sleep continuity. Springer-Verlag, 1992 Depression nationallicence Sleep nationallicence EEG nationallicence Antidepressants nationallicence Trazodone nationallicence van Bemmel A. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut Havermans R. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut van Diest R. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 569-574 0033-3158 107:4<569 1992 107 213 https://doi.org/10.1007/BF02245272 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245272 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Bemmel A. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Havermans R. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- van Diest R. Department of Clinical Psychiatry, University of Limburg, P.O. Box 616, NL-6200 MD, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 569-574 0033-3158 107:4<569 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer