caa a22 4500 469120851 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245258 doi (NATIONALLICENCE)springer-10.1007/BF02245258 Flesinoxan shows antidepressant activity in a DRL 72-s screen [Elektronische Daten] [A. van Hest, M. van Drimmelen, B. Olivier] Schedules which selectively reinforce low rates of responding (DRL, differential reinforcement of low rate) distinguish between antidepressants and other types of drugs. In a DRL schedule a subject is required to pause for a specified minimum period of time between two consecutive responses in order to obtain a reinforcer. The dependent variables are rate of responding and rate of reinforcement. Response patterns of rats treated with clinically effective antidepressant drugs such as imipramine (2.0-32.0 mg/kg) or fluvoxamine (4.0-32.0 mg/kg) are characterized by a decrease in response rate and an increase in reinforcement rate. Treatment with the 5-HT1A agonist flesinoxan (0.1-3.0 mg/kg) also dose-dependently decreased response rates while at the same time increasing reinforcement rates. Chlordiazepoxide (2.5-20.0 mg/kg) and diazepam (0.25-2.0 mg/kg) had no effects in the present experiment.d-Amphetamine increased response rates at low doses (0.5-2.0 mg/kg), and decreased it at the higher doses (4.0 mg/kg), but reinforcement rates were unaltered. Overall analysis of the effects of haloperidol (0.02-0.32 mg/kg) showed decreased responding and increased reinforcement rates. Post hoc analysis, however, clearly differentiated between haloperidol's profile and that of the antidepressants. As such, the results of the present experiment show that flesinoxan might possess antidepressant activity in humans. Springer-Verlag, 1992 Flesinoxan nationallicence 5HT1A agonist nationallicence Serotonin nationallicence Antidepressants nationallicence Differential-reinforcement-of-low-rate (DRL) 72-s nationallicence Rat nationallicence van Hest A. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut van Drimmelen M. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut Olivier B. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 474-479 0033-3158 107:4<474 1992 107 213 https://doi.org/10.1007/BF02245258 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245258 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Hest A. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut NATIONALLICENCE 700 1- van Drimmelen M. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut NATIONALLICENCE 700 1- Olivier B. Department of Pharmacology, SOLVAY-DUPHAR b.v., Postbus 900, NL-1380 DA, Weesp, The Netherlands aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 474-479 0033-3158 107:4<474 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer