caa a22 4500 469120894 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245275 doi (NATIONALLICENCE)springer-10.1007/BF02245275 Effect of chronic treatment with dizocilpine (MK-801) on the behavioral response to dopamine receptor agonists in the rat [Elektronische Daten] [Rossella Dall'Olio, Ottavio Gandolfi, Nicola Montanaro] The D2 or D1 dopamine receptor blockers (−)-sulpiride or SCH 23390 antagonized, in a dose dependent manner, the hypermotility induced by the N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801 (0.25 mg/kg IP). MK-801 induced hyperactivity was not detected when rats were observed on days 7, 14 or 21 of 21 daily injections of MK-801. This lack of hyperactivity was also noted 5 days after the last administration of the repeated treatment with MK-801. The hypermotility induced by the D2 dopamine receptor agonist LY 171555 (0.3 mg/kg IP) was reduced 5 days following repeated treatment (21 days) with MK-801, while no change in the behavioral responses to the selective D1 agonist, SKF 38393, or the mixed D1/D2 agent apomorphine was detected. The results, although suggesting the involvement of dopaminergic pathways in the behavioral effect of MK-801, are conflicting with regard to the underlying mechanisms and to the adaptive changes of dopaminergic system following repeated NMDA receptor blockade. Springer-Verlag, 1992 MK-801 induced hypermotility nationallicence Repeated treatment nationallicence SCH 23390 nationallicence YM 09151 nationallicence 2 nationallicence LY 171555-induced hyperactivity nationallicence Rat nationallicence Dall'Olio Rossella Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut Gandolfi Ottavio Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut Montanaro Nicola Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 591-594 0033-3158 107:4<591 1992 107 213 https://doi.org/10.1007/BF02245275 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245275 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dall'Olio Rossella Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut NATIONALLICENCE 700 1- Gandolfi Ottavio Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut NATIONALLICENCE 700 1- Montanaro Nicola Department of Pharmacology, University of Bologna, Via Irnerio 48, I-40126, Bologna, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 591-594 0033-3158 107:4<591 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer