caa a22 4500 469120908 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245271 doi (NATIONALLICENCE)springer-10.1007/BF02245271 Differences in response to the aversive properties and activity effects of low dose ethanol in LAS and HAS selectively bred rats [Elektronische Daten] [Martin Schechter, Edward Krimmer] Rats selectively bred for high alcohol sleep times (HAS) and those that are less affected (LAS) by hypnotic doses (3.0-3.6 g/kg) of ethanol were tested for differential responses to the aversive effects of 1.0 g/kg ethanol in a conditioned place preference task. Likewise, the effects of 0.3-1.0 g/kg ethanol on spontaneous locomotor activity over a 30-min period, as well as the loss of righting reflex with a higher ethanol dose (3.0 g/kg), were determined in these animals. The LAS rats reacted more aversively to 1.0 g/kg during conditioned place aversion testing than the HAS animals and also had a shorter mean sleeping time following 3.0 g/kg ethanol. Furthermore, dose-related depression of spontaneous motor activity was seen in the HAS animals and not in the LAS animals over a 30-min period using doses of 0.3, 0.6, or 1.0 g/kg (10% w/v) ethanol. Taken together, the results indicate that the intoxicating sequelae of high ethanol doses, such as ataxia and sedation, may not be correlated with the aversive effects of low ethanol doses. Springer-Verlag, 1992 Ethanol nationallicence Conditioned place preference nationallicence Locomotor activity nationallicence HAS/LAS nationallicence Rats nationallicence Schechter Martin Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, 44272, Rootstown, OH, USA aut Krimmer Edward Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, 44272, Rootstown, OH, USA aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 564-568 0033-3158 107:4<564 1992 107 213 https://doi.org/10.1007/BF02245271 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245271 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schechter Martin Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, 44272, Rootstown, OH, USA aut NATIONALLICENCE 700 1- Krimmer Edward Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, 44272, Rootstown, OH, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 564-568 0033-3158 107:4<564 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer