caa a22 4500 469120924 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245264 doi (NATIONALLICENCE)springer-10.1007/BF02245264 Acute and chronic ethanol tolerance: operant behaviour in naive and ethanol tolerant rats [Elektronische Daten] [Arto Hiltunen, Torbjörn Järbe] The relationship between tolerance to ethanol and acute tolerance to ethanol was examined. One group of rats was given 1.8 g/kg ethanol, and another group was administered 18 ml/kg saline for 26 days after sessions. Animals responded under a fixed ratio ten (FR-10) schedule of food reinforcement. Thereafter, various doses of ethanol (1.3-2.5 g/kg) were examined to assess the influence of the ethanol treatment on the expression of acute tolerance. Acute tolerance was assessed by comparing the performance at equal concentrations of ethanol on the ascending and the descending limbs of the ethanol concentration curve. This was achieved by varying the time between behavioural tests since ethanol administration. Ethanol concentrations were estimated using a rebreathed air procedure. Equal concentrations of ethanol were achieved with doses of i) 1.3 g/kg (10 min post-injection, PI), and 1.8 g/kg (60 min PI), as well as with doses of ii) 2.0 g/kg (10 min PI), and 2.5 g/kg (60 min PI). Acute tolerance was demonstrated for the initially ethanol naive animals. For the animals given ethanol chronically, only doses of ethanol higher than the chronically administered dose produced evidence for acute tolerance. When the chronically dosed animals had been off ethanol for 67 days, there was evidence for acute tolerance. The present data add to the generality of the acute ethanol tolerance phenomenon, and emphasize both the appearance as well as the loss of tolerance for this effect. Springer-Verlag, 1992 Acute tolerance nationallicence Tolerance nationallicence Interaction nationallicence Ethanol nationallicence Operant nationallicence FR-10 nationallicence Rats nationallicence Hiltunen Arto Department of Psychology, University of Uppsala, P.O. Box 1854, S-751 48, Uppsala, Sweden aut Järbe Torbjörn Department of Psychology, University of Uppsala, P.O. Box 1854, S-751 48, Uppsala, Sweden aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 511-516 0033-3158 107:4<511 1992 107 213 https://doi.org/10.1007/BF02245264 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245264 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiltunen Arto Department of Psychology, University of Uppsala, P.O. Box 1854, S-751 48, Uppsala, Sweden aut NATIONALLICENCE 700 1- Järbe Torbjörn Department of Psychology, University of Uppsala, P.O. Box 1854, S-751 48, Uppsala, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 511-516 0033-3158 107:4<511 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer