caa a22 4500 469120932 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920601xx s 000 0 eng 10.1007/BF02245274 doi (NATIONALLICENCE)springer-10.1007/BF02245274 Morphine, d -Pen2, d -Pen5 enkephalin and U50,488H differentially affect the locomotor activity and behaviours induced by quinpirole in guinea-pigs [Elektronische Daten] [Paul Brent, George Bot] The effects of morphined-Pen2,d-Pen5 enkephalin (DPDPE) and U50,488H on the behavioural syndrome elicited by the dopamine (DA) D-2 agonist quinpirole, were investigated. Morphine (1, 5 and 15 mg/kg SC) and morphine administered intracerebroventricularly (ICV) (2×5 µl, 10−3 M; total dose = 10 nmol) produced piloerection and sedation. DPDPE-ICV (2×5 µl and 2×10 µl, 10−3 M; total doses = 10 and 20 nmol) produced piloerection and sedation similar to morphine. U50,488H (1 mg/kg SC) induced locomotor activity and some stereotyped behaviour, whereas U50,488H (5 and 10 mg/kg SC) induced muscle rigidity and dystonic-like movements. The locomotor and behavioural response elicited by quinpirole (3 mg/kg IP) was attenuated in guinea-pigs pretreated with morphine (1, 5 and 15 mg/kg SC), morphine-ICV (2 × 5 µl, 10−3 M), and DPDPE-ICV (2 × 5 µl and 2 × 10 µl, 10−3 M). These effects were reversed by naloxone (15 mg/kg SC). U50,488H (1 mg/kg SC) increased the quinpirole-induced locomotor activity, whereas U50,488H (5 and 10 mg/kg SC) decreased the locomotor activity and stereotyped behaviours produced by quinpirole. These results indicate that the gross behavioural effects of mu, delta and kappa opioids differ in guinea-pigs compared to other rodent species, and suggest differential involvement of these opioid receptor subtypes with DA D-2 receptor-mediated activity. Springer-Verlag, 1992 Morphine nationallicence d -Pen2, d -Pen5 enkephalin nationallicence U50,488H nationallicence Quinpirole nationallicence Locomotor activity nationallicence Guineapig nationallicence Brent Paul Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, NSW, Australia aut Bot George Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, NSW, Australia aut Psychopharmacology Springer-Verlag 107/4(1992-06-01), 581-590 0033-3158 107:4<581 1992 107 213 https://doi.org/10.1007/BF02245274 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245274 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brent Paul Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, NSW, Australia aut NATIONALLICENCE 700 1- Bot George Neuropharmacology Laboratory, Faculty of Medicine, University of Newcastle, NSW, Australia aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 107/4(1992-06-01), 581-590 0033-3158 107:4<581 1992 107 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer