caa a22 4500 469120991 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253588 doi (NATIONALLICENCE)springer-10.1007/BF02253588 Effects of nicotine on hunger and eating in male and female smokers [Elektronische Daten] [Kenneth Perkins, Leonard Epstein, Joan Sexton, Rena Solberg-Kassel, Richard Stiller, Rolf Jacob] We tested whether the inverse relationship between smoking and body weight may be due in part to nicotine's acute effects on reducing hunger and eating. On four mornings, male and female smokers (n=10 each), abstinent overnight from smoking and food, received one of three nicotine doses (7.5, 15, and 30 µg/kg) or placebo (0) via nasal spray every 30 min for 2 h. Self-reported hunger and satiety ("fullness”) and craving for cigarettes were obtained after each dose presentation. Subjects subsequently ate ad lib from a large array of food items varying in sweet taste and fat content. For both males and females, nicotine had no effect on self-reported hunger, but cigarette craving was decreased. Rather than being decreased, caloric intake during the meal was unexpectedlyincreased following nicotine compared with placebo. Cigarette craving increased after the meal, and this increase was unaffected by nicotine dose. There were virtually no differences between males and females in any effects of nicotine. These results indicate that nicotine may not acutely suppress appetite in fasting smokers and suggest that other actions of nicotine or smoking may account for the lower body weights of smokers. Springer-Verlag, 1992 Nicotine nationallicence Satiety nationallicence Hunger nationallicence Caloric intake nationallicence Craving nationallicence Smokers nationallicence Males nationallicence Females nationallicence Sweet taste nationallicence Perkins Kenneth Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Epstein Leonard Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Sexton Joan Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Solberg-Kassel Rena Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Stiller Richard Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Jacob Rolf Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 53-59 0033-3158 106:1<53 1992 106 213 https://doi.org/10.1007/BF02253588 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253588 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perkins Kenneth Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Epstein Leonard Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Sexton Joan Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Solberg-Kassel Rena Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Stiller Richard Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Jacob Rolf Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, 15213, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 53-59 0033-3158 106:1<53 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer