caa a22 4500 469121009 CHVBK 20180323133138.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253593 doi (NATIONALLICENCE)springer-10.1007/BF02253593 Anxiolytic effect of carbamazepine in the elevated plus-maze: possible role of adenosine [Elektronische Daten] [H. Zangrossi Jr, J. Leite, F. Graeff] In order to extend previously reported observations with other animal models of anxiety, the effect of carbamazepine (CBZ) was presently measured in rats placed on the elevated plus-maze. Intraperitoneal injection of CBZ (5-40 mg/kg) increased the percentage of open arm entries as well as the percentage of time spent on the open arms of the maze, without affecting the total number of arm entries. This effect is characteristic of anxiolytic drugs. The inhibitor of adenosine neuronal uptake papaverine (5-40 mg/kg) caused a similar anxiolytic effect, whereas the adenosine receptor antagonist aminophylline (1-4 mg/kg) selectively decreased the percentage of open arm entries, indicative of an anxiogenic effect. Furthermore, the combination of an anxiogenic dose (4 mg/kg) of aminophylline with an anxiolytic dose (40 mg/kg) of CBZ resulted in cancellation of each other effects. Since reported neurochemical evidence shows that CBZ interacts with adenosine receptors, the present results provide preliminary support for a participation of this neurotransmitter in the anxiolytic action of CBZ. Springer-Verlag, 1992 Carbamazepine nationallicence Papaverine nationallicence Aminophylline nationallicence Elevated plus-maze nationallicence Adenosine nationallicence Anxiety nationallicence Rat nationallicence Zangrossi Jr H. Department of Pharmacology, FMRP, Campus of the University of São Paulo, 14049, Ribeirão Preto SP, Brazil aut Leite J. Department of Psychobiology, EPM, 04023, São Paulo SP, Brazil aut Graeff F. Department of Pharmacology, FMRP, Campus of the University of São Paulo, 14049, Ribeirão Preto SP, Brazil aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 85-89 0033-3158 106:1<85 1992 106 213 https://doi.org/10.1007/BF02253593 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253593 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zangrossi Jr H. Department of Pharmacology, FMRP, Campus of the University of São Paulo, 14049, Ribeirão Preto SP, Brazil aut NATIONALLICENCE 700 1- Leite J. Department of Psychobiology, EPM, 04023, São Paulo SP, Brazil aut NATIONALLICENCE 700 1- Graeff F. Department of Pharmacology, FMRP, Campus of the University of São Paulo, 14049, Ribeirão Preto SP, Brazil aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 85-89 0033-3158 106:1<85 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer