caa a22 4500 469121033 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253597 doi (NATIONALLICENCE)springer-10.1007/BF02253597 5-HT1A receptor-effector system responsivity in panic disorder [Elektronische Daten] [K. Lesch, M. Wiesmann, A. Hoh, T. Müller, J. Disselkamp-Tietze, M. Osterheider, H. Schulte] To explore 5-HT1A receptor responsivity in panic disorder (PD), hypothermic, neuroendocrine and behavioral responses to the selective partial 5-HT1A receptor agonist ipsapirone (IPS) were investigated in patients with primary PD and healthy controls. Fourteen patients and matched controls received a single oral dose of 0.3 mg/kg IPS or placebo under double-blind, random-assignment conditions. IPS induced hypothermia and corticotropin (ACTH)/cortisol release but had only minimal effects on behavior. Compared with controls, the patients with PD exhibited significantly attenuated thermoregulatory and neuroendocrine responses to IPS. Although the healthy subjects reported increased drowsiness and the PD patients rated themselves more nervous and less calm following administration of IPS, no consistent changes in ratings of anxiety or panic symptoms were recorded. The impaired hypothermic and ACTH/cortisol responses following 5-HT1A receptor activation reflects subsensitivity of both the pre- and post-synaptic 5-HT1A receptor-effector system, thus supporting the hypothesis that a 5-HT1A receptor-related serotonergic dysfunction may be linked to the pathophysiology of PD. Future studies of 5-HT1A receptor-effector complex function in conjunction with assessment of the responsivity of other subtypes (e.g. 5-HT2, 5-HT3) should promote the evaluation of 5-HT system integrity in anxiety disorders and its involvement in anxiolytic drug effects. Springer-Verlag, 1992 5-HT1A receptor nationallicence Ipsapirone nationallicence Hypothermia nationallicence ACTH nationallicence Cortisol nationallicence Anxiety nationallicence Panic disorder nationallicence Lesch K. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Wiesmann M. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Hoh A. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Müller T. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Disselkamp-Tietze J. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Osterheider M. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut Schulte H. Department of Medicine I, University of Kiel, W-2300, Kiel, Federal Republic of Germany aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 111-117 0033-3158 106:1<111 1992 106 213 https://doi.org/10.1007/BF02253597 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253597 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lesch K. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Wiesmann M. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Hoh A. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Müller T. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Disselkamp-Tietze J. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Osterheider M. Department of Psychiatry, University of Würzburg, W-8700, Würzburg, Federal Republic of Germany aut NATIONALLICENCE 700 1- Schulte H. Department of Medicine I, University of Kiel, W-2300, Kiel, Federal Republic of Germany aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 111-117 0033-3158 106:1<111 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer