caa a22 4500 46912105X CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253584 doi (NATIONALLICENCE)springer-10.1007/BF02253584 Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats [Elektronische Daten] [Philippe Chopin, Mike Briley] Amnesia can be induced in rats in the passive avoidance paradigm by administration of scopolamine, a central muscarinic receptor antagonist. Tacrine or galanthamine, inhibitors of acetylcholinesterase, given in conjunction with scopolamine partially reversed the scopolamine-induced deficit in passive avoidance performance. Four so-called cognitive enhancers, all widely used for the treatment of the symptoms associated with mental aging, cerebral insufficiency and senile memory disorder, were investigated in this paradigm. Piracetam, an extract of Ginkgo biloba, dihydroergocristine and a combination of raubasine with dihydroergocristine, all attenuated the amnesia induced by scopolamine. In contrast, nicergoline had no significant effect. Raubasine alone also failed to significantly attenuate scopolamine-induced amnesia, although some doses of raubasine had a non-significant tendency (P<0.10) to reduce the amnesia. Springer-Verlag, 1992 Scopolamine-induced amnesia nationallicence Passive avoidance nationallicence Tacrine nationallicence Galanthamine nationallicence Ginkgo biloba nationallicence Piracetam nationallicence Nicergoline nationallicence Raubasine nationallicence Dihydroergocristine nationallicence Chopin Philippe Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F-81106, Castres, France aut Briley Mike Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F-81106, Castres, France aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 26-30 0033-3158 106:1<26 1992 106 213 https://doi.org/10.1007/BF02253584 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253584 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chopin Philippe Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F-81106, Castres, France aut NATIONALLICENCE 700 1- Briley Mike Centre de Recherche Pierre Fabre, 17 avenue Jean Moulin, F-81106, Castres, France aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 26-30 0033-3158 106:1<26 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer