caa a22 4500 469121068 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253595 doi (NATIONALLICENCE)springer-10.1007/BF02253595 Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat [Elektronische Daten] [P. Grasby, T. Sharp, T. Allen, P. Kelly, D. Grahame-Smith] The azospirones gepirone (10 mg/kg), ipsapirone (10 mg/kg) and buspirone (10 mg/kg) were examined for their effect on regional cerebral glucose utilization in conscious rats using quantitative 2-deoxyglucose autoradiography. All three 5-HT1A partial agonists reduced glucose utilization in the hippocampus and dentate gyrus by 20-25% and increased glucose utilization by 38-65% in the lateral habenular nucleus; an important relay between striatal/limbic areas and the mid-brain raphe nuclei. The findings emphasize the potential importance of the hippocampus as a site of action for 5-HT1A receptor active drugs in vivo and also suggest that functional activity in the striatal/limbichabenular-raphe pathway may be influenced by gepirone, ipsapirone and buspirone. Springer-Verlag, 1992 Gepirone nationallicence Buspirone nationallicence Ipsapirone nationallicence Glucose utilization nationallicence Hippocampus nationallicence Lateral habenular nucleus nationallicence Grasby P. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Sharp T. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Allen T. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Kelly P. Department of Clinical Neuroscience, Western General Infirmary, Crewe Road, EH4 2XU, Edinburgh, UK aut Grahame-Smith D. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 97-101 0033-3158 106:1<97 1992 106 213 https://doi.org/10.1007/BF02253595 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253595 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grasby P. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 700 1- Sharp T. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 700 1- Allen T. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 700 1- Kelly P. Department of Clinical Neuroscience, Western General Infirmary, Crewe Road, EH4 2XU, Edinburgh, UK aut NATIONALLICENCE 700 1- Grahame-Smith D. Radcliffe Infirmary, MRC Unit and University Department of Clinical Pharmacology, Woodstock Road, OX2 6HE, Oxford, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 97-101 0033-3158 106:1<97 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer