caa a22 4500 469121114 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253601 doi (NATIONALLICENCE)springer-10.1007/BF02253601 Noradrenergic receptor mechanisms in neophobia [Elektronische Daten] [Jeffery Steketee, Peter Silverman, Alan Swann] We have previously demonstrated that depletion of forebrain norepinephrine (NE) led to an attenuation of neophobia in a novel environment, as defined by a greater preference for novel food over familiar food. To study further the role of forebrain NE in neophobia we chronically infused noradrenergic receptor ligands or forskolin into the lateral ventricles of sham and 6-hydroxydopamine dorsal bundle lesioned rats. Chronic NE infusions into lesioned animals reversed the lesion-induced shift in relative food preference. The beta receptor agonist isoproterenol had moderate effects similar to those of NE in lesioned and sham animals. Phenylephrine, an alpha-1 agonist, was without effect. Forskolin, an adenylate cyclase activator, mimicked the effects of NE infusions. These data suggest a role for noradrenergic stimulation of adenylate cyclase in neophobia. Springer-Verlag, 1992 Norepinephrine nationallicence Dorsal noradrenergic bundle nationallicence 6-OHDA nationallicence Isoproterenol nationallicence Phenylephrine nationallicence Clonidine nationallicence Forskolin nationallicence Neophobia nationallicence Food preference nationallicence Steketee Jeffery Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut Silverman Peter Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut Swann Alan Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 136-142 0033-3158 106:1<136 1992 106 213 https://doi.org/10.1007/BF02253601 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253601 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steketee Jeffery Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Silverman Peter Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut NATIONALLICENCE 700 1- Swann Alan Department of Psychiatry and Behavioral Sciences, University of Texas Medical School at Houston and University of Texas Mental Sciences Institute, P.O. Box 77225, 77225, Houston, TX, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 136-142 0033-3158 106:1<136 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer