caa a22 4500 469121122 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253582 doi (NATIONALLICENCE)springer-10.1007/BF02253582 D1 dopamine receptor binding in mood disorders measured by positron emission tomography [Elektronische Daten] [Tetsuya Suhara, Kazuhiko Nakayama, Osamu Inoue, Hiroshi Fukuda, Makoto Shimizu, Atuyoshi Mori, Yukio Tateno] D1 dopamine receptor binding in mood disorders was studied by positron emission tomography (PET) using11C-SCH23390. Ten patients with bipolar mood disorders and 21 normal controls were studied in the drug-free state. The patients were in euthymic (N=6), depressed (N=3) and manic (N=1) states. Regional radioactivity in the brain was followed for 40 min by PET. A two-compartment model was used to obtain the binding potential (k3/k4) for the striatum and frontal cortex. The binding potentials for the frontal cortex for the patients were significantly lower than those for normal controls, whereas those for striatum were not significantly different. These findings suggest that D1 dopamine receptors in the frontal cortex may be in a different state in patients with bipolar mood disorders. Springer-Verlag, 1992 Positron emission tomography nationallicence Mood disorders nationallicence D1 dopamine receptors nationallicence SCH23390 nationallicence Frontal cortex nationallicence Suhara Tetsuya Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut Nakayama Kazuhiko Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut Inoue Osamu Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut Fukuda Hiroshi Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut Shimizu Makoto Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut Mori Atuyoshi Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut Tateno Yukio Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 14-18 0033-3158 106:1<14 1992 106 213 https://doi.org/10.1007/BF02253582 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253582 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suhara Tetsuya Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut NATIONALLICENCE 700 1- Nakayama Kazuhiko Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut NATIONALLICENCE 700 1- Inoue Osamu Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut NATIONALLICENCE 700 1- Fukuda Hiroshi Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut NATIONALLICENCE 700 1- Shimizu Makoto Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut NATIONALLICENCE 700 1- Mori Atuyoshi Department of Psychiatry, Jikei University School of Medicine, 25-8 Nishishinbashi 3-chome, Minato-ku, 105, Tokyo, Japan aut NATIONALLICENCE 700 1- Tateno Yukio Division of Clinical Research, National Institute of Radiological Sciences, 9-1 Anagawa 4-chome, 260, Chiba-shi, Japan aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 14-18 0033-3158 106:1<14 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer