caa a22 4500 469121165 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253581 doi (NATIONALLICENCE)springer-10.1007/BF02253581 Ståhle Lars Department of Pharmacology, Karolinska Institute, S-Stockholm, Sweden aut Do autoreceptors mediate dopamine agonist — induced yawning and suppression of exploration? A critical review [Elektronische Daten] [Lars Ståhle] The hypothesis that stimulation of dopamine autoreceptors is the mechanism by which dopamine agonists induce yawning and suppression of exploration is critically examined. It is shown that the relation between reduced extracellular dopamine levels, assessed by microdialysis, and behavioural effects of dopamine agonists, a dopamine synthesis inhibitor and a granule storage blocker is highly inconsistent. The time-course and duration of the behavioural effects of dopamine agonists differ from the reduction of extracellular dopamine. Amphetamine cotreatment is shown to increase dopamine levels, while yawning and suppression of exploration can still be induced. The data strongly indicate that autoreceptors are not the mediators of these behavioural effects. It is proposed that postsynaptic receptors mediate dopamine agonist induced yawning and suppression of exploration. Evidence is also presented showing that yawning and suppression of exploration are not functionally equivalent. Springer-Verlag, 1992 Dopamine agonist nationallicence Autoreceptors nationallicence Yawning nationallicence Suppression of exploration nationallicence Psychopharmacology Springer-Verlag 106/1(1992-01-01), 1-13 0033-3158 106:1<1 1992 106 213 https://doi.org/10.1007/BF02253581 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253581 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ståhle Lars Department of Pharmacology, Karolinska Institute, S-Stockholm, Sweden aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 1-13 0033-3158 106:1<1 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer