caa a22 4500 469121173 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920101xx s 000 0 eng 10.1007/BF02253599 doi (NATIONALLICENCE)springer-10.1007/BF02253599 Effect of peripheral administration of cinnarizine and verapamil on the abstinence syndrome in diazepam-dependent rats [Elektronische Daten] [Yati Chugh, N. Saha, A. Sankaranarayanan, P. Sharma] The effects of two calcium channel blockers (verapamil and cinnarizine) were evaluated on diazepam withdrawal symptoms. Rats were made diazepam dependent by chronic treatment with daily injections of the drug, 20 mg/kg IP for 3 weeks. On abrupt termination of the drug, animals showed withdrawal hyperactivity that was assessed by autonomic, behavioural and motor signs. The peak effect was seen 3 days after the withdrawal of diazepam. On IP administration, verapamil and cinnarizine (10, 20 and 40 mg/kg) given on eight occasions at an interval of 12 h reversed the withdrawal-induced increase in spontaneous motor activity. Cinnarizine in higher doses (20 and 40 mg/kg) was found to be effective in suppressing the behavioural signs but verapamil did not show any protective effect against startle response and irritability. These results suggest that modulation of the calcium influx in the CNS might influence withdrawal. Springer-Verlag, 1992 Verapamil nationallicence Cinnarizine nationallicence Diazepam nationallicence Withdrawal hyperactivity nationallicence Rat nationallicence Chugh Yati Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Saha N. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Sankaranarayanan A. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Sharma P. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut Psychopharmacology Springer-Verlag 106/1(1992-01-01), 127-130 0033-3158 106:1<127 1992 106 213 https://doi.org/10.1007/BF02253599 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02253599 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chugh Yati Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Saha N. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Sankaranarayanan A. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 700 1- Sharma P. Department of Pharmacology, Postgraduate Institute of Medical Education and Research, 160012, Chandigarh, India aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/1(1992-01-01), 127-130 0033-3158 106:1<127 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer