caa a22 4500 46912119X CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245426 doi (NATIONALLICENCE)springer-10.1007/BF02245426 Effects of chronically administered fluoxetine and fenfluramine on food intake, body weight and the behavioural satiety sequence [Elektronische Daten] [Joan McGuirk, Richard Muscat, Paul Willner] Rats were administered fenfluramine (FF: 3 mg/kg) or fluoxetine (FX: 6 mg/kg) daily for 3 weeks. On acute administration, FF suppressed consumption of 35% sucrose (in a 40 min test) and overnight chow intake. Repeated administration saw the rapid development of extensive tolerance to these effects. FF had no effects on body weight, and no withdrawal effects were apparent. FX reduced chow intake and body weight throughout the treatment period, but there was evidence of some tolerance to the suppression of chow intake and sucrose drinking. Following FX withdrawal, normal body weight was restored in 4 days; food intake was normal during this period. A delayed rebound hyperphagia commenced on day 5 of withdrawal, and persisted for at least 6 days. The behavioural satiety sequence (drinking -activity - grooming - resting) was disrupted by acute FF; on chronic treatment, FF advanced the onset of postprandial resting, but also increased drinking time. FX advanced the behavioural satiety sequence on acute administration, but not after chronic treatment. We consider the implications of these results for the use of resting behaviour as an indicator of postprandial satiety. Springer-Verlag, 1992 Feeding nationallicence Body weight nationallicence Fluoxetine nationallicence Fenfluramine nationallicence Behavioural satiety sequence nationallicence Chronic drug treatment nationallicence Rat nationallicence McGuirk Joan Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 401-407 0033-3158 106:3<401 1992 106 213 https://doi.org/10.1007/BF02245426 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245426 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGuirk Joan Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Muscat Richard Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 700 1- Willner Paul Psychology Department, City of London Polytechnic, Old Castle Street, E1 7NT, London, UK aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 401-407 0033-3158 106:3<401 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer