caa a22 4500 469121203 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245422 doi (NATIONALLICENCE)springer-10.1007/BF02245422 Cocaine enhances retention of avoidance conditioning in rats [Elektronische Daten] [Patricia Janak, Geoffrey Keppel, Joe Martinez Jr] The effects of post-training cocaine administration were tested on retention of a one-way active avoidance task in rats. A 5.0 mg/kg IP dose of cocaine enhanced retention of the avoidance task, in three separate experiments, as indicated by an increase in the number of avoidances made when animals were tested 24 h after training, while both a lower (2.5 mg/kg) and a higher (7.5 mg/kg) cocaine dose had no effect. Lidocaine (4-8 mg/kg) administered post-training did not reliably affect retention in the same task. Cocaine's ability to enhance retention depended on the interval between training and drug injection such that only cocaine administered directly after training enhanced retention the following day. The results show that post-training cocaine administration enhances retention of an active avoidance task in rats, and that this effect is probably independent of the anesthetic properties of the drug. Springer-Verlag, 1992 Cocaine nationallicence Memory nationallicence Active avoidance nationallicence Retention nationallicence Time dependency nationallicence Lidocaine nationallicence Rat nationallicence Janak Patricia Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Keppel Geoffrey Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Martinez Jr Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 383-387 0033-3158 106:3<383 1992 106 213 https://doi.org/10.1007/BF02245422 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245422 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Janak Patricia Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Keppel Geoffrey Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 700 1- Martinez Jr Joe Department of Psychology, University of California, 3210 Tolman Hall, 94720, Berkeley, CA, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 383-387 0033-3158 106:3<383 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer