caa a22 4500 469121246 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245418 doi (NATIONALLICENCE)springer-10.1007/BF02245418 Corticotropin releasing factor (CRF): studies in alcohol preferring and non-preferring rats [Elektronische Daten] [C. Ehlers, R. Chaplin, T. Wall, L. Lumeng, T. Li, M. Owens, C. Nemeroff] Electroencephalographic (EEG) responses to corticotropin releasing factor (CRF) as well as CRF concentrations in several brain regions were measured in two lines of rats which have been genetically selected for alcohol preferring (P) or non-preferring (NP) behaviors. Fifteen rats were implanted with chronic electrodes and EEG spectra were evaluated following intracerebroventricular (ICV) administration of CRF (0.15 nmol) or saline. P rats demonstrated a significantly increased EEG response to CRF in the theta frequency range (ANOVA: PREF × DRUG 4-6 Hz,P<0.03; 6-8 Hz,P<0.05) in frontal cortex. A significantly lower concentration of CRF was found in the P rats in hypothalamus (P<0.02), amygdala (P<0.003), prefrontal cortex (P<0.01), and cingulate cortex (P<0.02). The finding that P rats had an increased response to exogenously administered CRF, taken together with decreased CRF concentrations, suggests that CRF receptors may be up-regulated in these animals. Differences in the regulation of CRF neurons may contribute to the expression of behavioral preference for ethanol consumption in these rat lines. Springer-Verlag, 1992 Alcohol-preferring rats nationallicence Electroencephalogram (EEG) nationallicence Spectral analysis nationallicence Corticotropin releasing factor (CRF) nationallicence Hypothalamic-pituitary-adrenal (HPA) axis nationallicence Ehlers C. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut Chaplin R. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut Wall T. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut Lumeng L. School of Medicine and VAMC, Indiana University, Indianapolis, IN, USA aut Li T. School of Medicine and VAMC, Indiana University, Indianapolis, IN, USA aut Owens M. Department of Psychiatry, Duke University Medical Center, 27710, Durham, NC, USA aut Nemeroff C. Department of Psychiatry, Duke University Medical Center, 27710, Durham, NC, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 359-364 0033-3158 106:3<359 1992 106 213 https://doi.org/10.1007/BF02245418 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245418 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ehlers C. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Chaplin R. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Wall T. Department of Neuropharmacology, Research Institute of the Scripps Clinic, 10666 North Torrey Pines Road, BCR-1, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Lumeng L. School of Medicine and VAMC, Indiana University, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Li T. School of Medicine and VAMC, Indiana University, Indianapolis, IN, USA aut NATIONALLICENCE 700 1- Owens M. Department of Psychiatry, Duke University Medical Center, 27710, Durham, NC, USA aut NATIONALLICENCE 700 1- Nemeroff C. Department of Psychiatry, Duke University Medical Center, 27710, Durham, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 359-364 0033-3158 106:3<359 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer