caa a22 4500 469121262 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245419 doi (NATIONALLICENCE)springer-10.1007/BF02245419 An examination of the anticonvulsant properties of voltage-sensitive calcium channel inhibitors in amygdala kindled seizures [Elektronische Daten] [C. Mack, M. Gilbert] Voltage-sensitive calcium (VSC) channels may contribute to epileptogenesis. A systematic examination of the anticonvulsant efficacy of different classes of VSC channel inhibitors, however, is lacking in chronic seizure models. The present study evaluated representatives from three different classes of VSC channel inhibitors for their protection against amygdala kindled seizures. Adult male rats (n=12) were kindled to stage 5 seizures (GS), and a threshold intensity required to evoke a GS was determined. The Ca++-channel inhibitors (verapamil 0, 10, 20, 40 mg/kg; nimodipine 0, 5, 25, 50 mg/kg; nitrendipine 0, 25, 50, 100 mg/kg and flunarizine 0, 20, 40, 80 mg/kg) were administered 60-90 min prior to amygdala stimulation at the established threshold. None of the drugs altered threshold for inducing a seizure. Verapamil, a phenylalkylamine, and the dihydropyridines nimodipine and nitrendipine were without effect on kindled seizures. The diphenylalkylamine, flunarizine, was found to be the most efficacious, reducing AD duration and duration of clonic seizure activity by more than 60% in most animals. Flunarizine also decreased the severity of behavioral seizures, with 40% of the animals displaying Stage 1-2 seizures only. It is concluded that some VSC Ca++-channel inhibitors do possess anticonvulsant potential. Thus influx of extracellular calcium through VSC channels may contribute to the expression of kindled seizures. Springer-Verlag, 1992 Calcium nationallicence Kindled amygdala nationallicence Verapamil nationallicence Nimodipine nationallicence Nitrendipine nationallicence Flunarizine nationallicence Calcium channel antagonist nationallicence Seizures nationallicence Anticonvulsant nationallicence Mack C. Mantech Environmental Technology Incorporated, 27711, Research Triangle Park, NC, USA aut Gilbert M. Mantech Environmental Technology Incorporated, 27711, Research Triangle Park, NC, USA aut Psychopharmacology Springer-Verlag 106/3(1992-03-01), 365-369 0033-3158 106:3<365 1992 106 213 https://doi.org/10.1007/BF02245419 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245419 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mack C. Mantech Environmental Technology Incorporated, 27711, Research Triangle Park, NC, USA aut NATIONALLICENCE 700 1- Gilbert M. Mantech Environmental Technology Incorporated, 27711, Research Triangle Park, NC, USA aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 365-369 0033-3158 106:3<365 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer