caa a22 4500 469121270 CHVBK 20180323133139.0 cr unu---uuuuu 170328e19920301xx s 000 0 eng 10.1007/BF02245425 doi (NATIONALLICENCE)springer-10.1007/BF02245425 Persico A. Drug Dependence Unit, Policlinico A. Gemelli, Catholic University of the Sacred Heart, I-00168, Rome, Italy aut Persistent decrease in heart rate after smoking cessation: A 1-year follow-up study [Elektronische Daten] [A. Persico] The heart rate of 11 smokers was collected throughout their first year of abstinence. One day after smoking cessation, we recorded a significant mean heart rate drop of 9.07 beats per min, from 74.18 to 65.11 beats per min. No significant variation was afterwards detected at any chosen time point (week 1, 2, 3, 4, 6, month 3, 6, 12). In fact, 1 year after cessation the mean heart rate was still 66.36 beats per min, well below initial baseline values. These data indicate that the decrease in heart rate following smoking cessation mostly represents a permanent return to individual normal values in the absence of nicotine self-administration. Nonetheless, three subjects did show a trend toward the recovery of their precessation heart rate and one subject fully recovered it between months 3 and 6 of abstinence. This trend suggests that, while heart rate adaptation to nicotine is largely of an acute nature, there may also be a chronic component. Its role, though usually minor, should become detectable in a few subjects, because of wide interindividual variability. Springer-Verlag, 1992 Heart rate nationallicence Smoking cessation nationallicence Nicotine tolerance nationallicence Nicotine withdrawal nationallicence Psychopharmacology Springer-Verlag 106/3(1992-03-01), 397-400 0033-3158 106:3<397 1992 106 213 https://doi.org/10.1007/BF02245425 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02245425 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Persico A. Drug Dependence Unit, Policlinico A. Gemelli, Catholic University of the Sacred Heart, I-00168, Rome, Italy aut NATIONALLICENCE 773 0- Psychopharmacology Springer-Verlag 106/3(1992-03-01), 397-400 0033-3158 106:3<397 1992 106 213 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer